SUPT16H [nucleoplasm]

Stable Identifier
R-HSA-112415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
FACT 140 kDa subunit
Locations in the PathwayBrowser for interactor UniProt:Q9UPN9%20TRIM33
General
DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb.
External Reference Information
External Reference
Gene Names
SUPT16H, FACT140, FACTP140
Chain
initiator methionine:, chain:2-1047
Reference Transcript
Other Identifiers
11198
11717114_a_at
16790267
217815_PM_at
217815_at
233827_PM_s_at
233827_s_at
3446084
3446086
3446094
3446097
3446099
3446101
3446103
3446107
3446108
3446109
3556324
3556325
3556326
3556327
3556329
3556330
3556331
3556333
3556334
3556336
3556337
3556338
3556339
3556340
3556341
3556342
3556343
3556344
3556345
3556346
3556347
3556348
3556349
3556350
3556352
3556353
3556354
3556356
3556358
3556364
3556365
3556366
57040_at
68143_at
7977674
90470_r_at
A_23_P151634
A_24_P153800
GE58441
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006260
GO:0006281
GO:0006325
GO:0006334
GO:0006337
GO:0006351
GO:0006355
GO:0006366
GO:0006368
GO:0006974
GO:0031491
GO:0032786
GO:0035101
GO:0043226
GO:0065003
HMNXSV003007434
Hs.14963.1.S1_3p_a_at
ILMN_1781516
TC14000916.hg
g6005756_3p_at
Participates
Inferred To
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Pharos - Targets
Orphanet
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q08945 SSRP1  1 0.855 7
 UniProt:P33991 MCM4  1 0.602 3
 UniProt:P68431 HIST1H3G  20 0.569 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:Q99459 CDC5L  1 0.547 2
 UniProt:P16104 H2AFX  7 0.527 2
 UniProt:Q01831 XPC  5 0.527 2
 UniProt:P10636-8 MAPT  3 0.527 6
 UniProt:Q9UGP5 POLL  1 0.508 2
 UniProt:P50750 CDK9  1 0.462 3
 UniProt:Q9UPN9 TRIM33  1 0.462 3
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