Reactome | TCEB2 [nucleoplasm]

TCEB2 [nucleoplasm]

Stable Identifier

R-HSA-112423

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Elongin C protein, Transcription elongation factor B polypeptide 2, RNA polymerase II transcription factor SIII subunit B, SIII p18, Elongin B, EloB, Elongin 18 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:P40337 VHL

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External Reference Information

External Reference

UniProt:Q15370 ELOB

Gene Names

ELOB, TCEB2

Chain

chain:1-118

Reference Genes

BioGPS Gene:6923 ELOB

COSMIC (genes):ELOB ELOB

CTD Gene:6923 ELOB

dbSNP Gene:6923 ELOB

ENSEMBL:ENSG00000103363 ELOB

HGNC:11619 ELOB

KEGG:hsa:6923 ELOB

Monarch:6923 ELOB

NCBI Gene:6923 ELOB

OMIM:600787 ELOB

UCSC:Q15370 ELOB

Reference Transcript

Participates

as an input of

Formation of Elongin BC complex (Homo sapiens)

as a component of

Other forms of this molecule

ELOB [cytosol]

Inferred To

Elob [nucleoplasm] (Mus musculus)

Elob [nucleoplasm] (Rattus norvegicus)

TCEB2 [nucleoplasm] (Bos taurus)

TCEB2 [nucleoplasm] (Canis familiaris)

elb-1 [nucleoplasm] (Caenorhabditis elegans)

elob [nucleoplasm] (Xenopus tropicalis)

ELOB [nucleoplasm] (Sus scrofa)

EloB [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of TCEB2 [nucleoplasm] (Danio rerio)

Ghost homologue of TCEB2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of TCEB2 [nucleoplasm] (Gallus gallus)

Ghost homologue of TCEB2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of TCEB2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_009039.1, NP_996896.1

OpenTargets

ENSG00000103363

ENSEMBL

ENSP00000262306, ENST00000262306, ENSG00000103363, ENSP00000386652, ENST00000409906

HPA

ENSG00000103363-ELOB

GeneCards

ELOB

PRO

Q15370

Pharos - Targets

Q15370

GlyGen

Q15370

PDB

6I5J, 4AWJ, 7ZLO, 7M6T, 8QJR, 8EBN, 6R7I, 6GMQ, 6R7N, 5NVX, 4W9G, 8BB5, 6GMX, 8JE1, 8FY2, 3DCG, 8VL9, 8SH2, 8BDS, 4W9I, 8JAR, 8OF0, 3ZTD, 8G1Q, 8BDI, 8BDN, 7PI4, 2IZV, 6GFZ, 8FVJ, 6HR2, 7Q2J, 8OEW, 8C13, 8CQK, 9D1Z, 8CX0, 8CX2, 8WQG, 9EQM, 2MA9, 8WQC, 7UPN, 7ZLN, 8EWV, 8ZVJ, 7ZLS, 7Z77, 8BB4, 6GMN, 5NVV, 8P0F, 8R5H, 8BDJ, 8BDL, 8JAS, 5NVY, 6R7H, 7Z6L, 7KHH, 8FY1, 9BJU, 8RWZ, 8G1P, 5T35, 8QW7, 4W9L, 4W9C, 6SIS, 8PQL, 4AJY, 6GFX, 5BO4, 3ZKJ, 9D8P, 6BVB, 6FMK, 8PC2, 4BKT, 1LM8, 9D1Y, 4N9F, 8WQF, 6ZHC, 9EQJ, 8Y1U, 8CX1, 8WQB, 8IJ1, 2JZ3, 6I5N, 7ZLM, 7JTP, 8CQE, 8QJS, 4B95, 5NW0, 7CJB, 8BB3, 4W9F, 6HAY, 4W9H, 5NVZ, 3ZTC, 8JAV, 8BDT, 4WQO, 1LQB, 4W9K, 6I7Q, 3ZRF, 6R7F, 3ZUN, 8BDO, 8QW6, 8JAQ, 7PLO, 6I7R, 6P59, 9BOL, 6R6H, 8FVI, 6FMI, 6GFY, 4BKS, 8WDK, 6I4X, 8ZV8, 6V9H, 6C5X, 8WQE, 7JTO, 7ZLP, 7ZLR, 3ZNG, 8BB2, 8QU8, 7Z76, 2C9W, 5NW1, 5N4W, 5NVW, 8Q7R, 8BEB, 8OEV, 6HAX, 5NW2, 8JAU, 7ZNT, 8OL1, 8FY0, 8BDM, 8JE2, 3ZRC, 8JAL, 4W9J, 8BDX, 8OKX, 6GMR, 7S4E, 1VCB, 4W9D, 8VLB, 8QVU, 4W9E, 8CQL, 8RX0, 6FMJ, 5LLI, 4B9K, 8EI3, 8WQH, 9D1I, 8SZK, 8WQA

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.952	20
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.944	14
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) HN-HIF1A [cytosol] (R-HSA-1234110)	0.789	8
UniProt:Q9UHY1 NRBP1	1	NRBP1 [nucleoplasm] (R-HSA-376332)	0.725	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.725	18
UniProt:P78395 PRAME			0.676	7
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.643	4
UniProt:A0A663DJA2 ORF10			0.643	3
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.643	8
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.642	4
UniProt:P12504 VIF			0.558	5
UniProt:Q96EL3 MRPL53	1	MRPL53 [mitochondrial inner membrane] (R-HSA-5368226)	0.556	5
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	5
UniProt:P40337-3 VHL			0.547	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.527	3
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.527	2
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	2
UniProt:Q9Y2U9 KLDC2			0.527	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.527	3
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3

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