Reactome | NELFA [nucleoplasm]

NELFA [nucleoplasm]

Stable Identifier

R-HSA-112426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NELF-A protein, Negative elongation factor A, NELF-A, Wolf-Hirshhorn syndrome candidate 2 protein, P/OKCL.15

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H3P2 NELFA

Gene Names

NELFA, WHSC2, P/OKcl.15

Chain

chain:1-528

Reference Genes

BioGPS Gene:7469 NELFA

COSMIC (genes):NELFA NELFA

CTD Gene:7469 NELFA

dbSNP Gene:7469 NELFA

ENSEMBL:ENSG00000185049 NELFA

HGNC:12768 NELFA

KEGG:hsa:7469 NELFA

Monarch:7469 NELFA

NCBI Gene:7469 NELFA

OMIM:606026 NELFA

UCSC:Q9H3P2 NELFA

Reference Transcript

RefSeq:NM_005663.4 NELFA

Other Identifiers

11743752_a_at

16973625

203112_PM_s_at

203112_s_at

2757541

2757542

2757543

2757544

2757546

2757547

2757548

2757549

2757550

2757551

2757552

2757553

2757554

2757555

2757556

2757557

2757558

2757560

2757561

2757562

2757563

2757564

2757565

2757566

2757567

2757568

2757577

2757579

2757581

2757582

2757583

2757586

2757588

2757593

2757595

34225_PM_at

34225_at

7469

8098942

A_23_P213216

A_24_P83183

GE55745

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0016604

GO:0031401

GO:0032021

GO:0034244

GO:0043226

GO:0045944

GO:0060090

HMNXSV003017203

HMNXSV003040455

ILMN_1815083

PH_hs_0001892

TC04000971.hg

g5032226_3p_s_at

Participates

as a component of

as an input of

Formation of NELF complex (Homo sapiens)

Inferred To

nelfa [nucleoplasm] (Danio rerio)

nelfa [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of NELFA [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of NELFA [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of NELFA [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of NELFA [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NELFA [nucleoplasm] (Schizosaccharomyces pombe)

Nelf-A [nucleoplasm] (Drosophila melanogaster)

Nelfa [nucleoplasm] (Mus musculus)

Nelfa [nucleoplasm] (Rattus norvegicus)

NELFA [nucleoplasm] (Bos taurus)

NELFA [nucleoplasm] (Canis familiaris)

NELFA [nucleoplasm] (Gallus gallus)

NELFA [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005654.3

OpenTargets

ENSG00000185049

ENSEMBL

ENST00000382882, ENSP00000372335

HPA

ENSG00000185049-NELFA

PRO

Q9H3P2

Pharos - Targets

Q9H3P2

Orphanet

NELFA

GlyGen

Q9H3P2

PDB

8RBX, 8W8E, 8UHG, 8UI0, 6GML, 7YCX, 8UIS, 8UHA, 5L3X, 7PKS, 8UHD

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.871	14
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.812	9
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.758	6
UniProt:Q8IXH7-4 NELFCD			0.737	5
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.643	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
IntAct:EBI-10220116 163154			0.556	3
IntAct:EBI-22412087 CCSB ORF ID			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q00526 CDK3			0.556	3
UniProt:Q9NXL9 MCM9			0.527	2
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	2
UniProt:Q86WR7 PRSR2			0.527	2
UniProt:P38935 SMBP2			0.527	3
UniProt:Q99689 FEZ1			0.527	2
UniProt:Q9NZQ9 TMOD4	1	TMOD4 [cytosol] (R-HSA-5694030)	0.527	2
UniProt:P24928 POLR2A	7	POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543)	0.527	2
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.508	2
UniProt:Q8IXH7-1 NELFCD			0.462	2

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