Reactome | NELFB [nucleoplasm]

NELFB [nucleoplasm]

Stable Identifier

R-HSA-112427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NELF-B protein, Negative elongation factor B, NELF-B, Cofactor of BRCA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8WX92 NELFB

Gene Names

NELFB, COBRA1, KIAA1182

Chain

chain:1-580

Reference Genes

BioGPS Gene:25920 Q8WX922

COSMIC (genes):NELFB NELFB

CTD Gene:25920 Q8WX922

dbSNP Gene:25920 Q8WX922

ENSEMBL:ENSG00000188986 NELFB

HGNC:24324 Q8WX922

KEGG:hsa:25920 Q8WX922

Monarch:25920 Q8WX922

NCBI Gene:25920 Q8WX922

OMIM:611180 Q8WX922

UCSC:Q8WX92 Q8WX922

Reference Transcript

RefSeq:NM_015456.4 Q8WX922

Participates

as a component of

as an input of

Formation of NELF complex (Homo sapiens)

Other forms of this molecule

NELFB [cytosol]

NELFB [mitochondrial outer membrane]

Inferred To

Nelfb [nucleoplasm] (Mus musculus)

Nelfb [nucleoplasm] (Rattus norvegicus)

NELF-B [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of NELFB [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of NELFB [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of NELFB [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NELFB [nucleoplasm] (Schizosaccharomyces pombe)

nelfb [nucleoplasm] (Danio rerio)

nelfb [nucleoplasm] (Xenopus tropicalis)

NELFB [nucleoplasm] (Bos taurus)

NELFB [nucleoplasm] (Canis familiaris)

NELFB [nucleoplasm] (Dictyostelium discoideum)

NELFB [nucleoplasm] (Gallus gallus)

NELFB [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000188986

ENSEMBL

ENSG00000188986, ENSP00000339495, ENST00000343053

HPA

ENSG00000188986-NELFB

GeneCards

NELFB

PRO

Q8WX92

Pharos - Targets

Q8WX92

GlyGen

Q8WX92

PDB

8W8E, 7YCX, 8JJ6, 8UI0, 8UHA, 8UHG, 8UHD, 7PKS, 8RBX, 6GML

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.906	9
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.758	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	3
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.602	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	3
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	3
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.524	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.524	2
UniProt:O43583 DENR			0.524	2
UniProt:P10620 MGST1	3	MGST1 [endoplasmic reticulum membrane] (R-HSA-158545) MGST1 [plasma membrane] (R-HSA-6806259) MGST1 [azurophil granule membrane] (R-HSA-6799226)	0.524	2

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