Reactome | NELFCD [nucleoplasm]

NELFCD [nucleoplasm]

Stable Identifier

R-HSA-112428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NELF-C/D protein, Negative elongation factor C/D, NELF-C/D, TH1-like protein, HSPC130

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IXH7 NELFCD

Gene Names

NELFCD, NELFD, TH1, TH1L, HSPC130

Chain

chain:1-590

Reference Genes

BioGPS Gene:51497 NELFCD

COSMIC (genes):NELFCD NELFCD

CTD Gene:51497 NELFCD

dbSNP Gene:51497 NELFCD

ENSEMBL:ENSG00000101158 NELFCD

HGNC:15934 NELFCD

KEGG:hsa:51497 NELFCD

Monarch:51497 NELFCD

NCBI Gene:51497 NELFCD

OMIM:605297 NELFCD

UCSC:Q8IXH7 NELFCD

Reference Transcript

RefSeq:NM_198976.2 NELFCD

Participates

as a component of

as an input of

Formation of NELF complex (Homo sapiens)

Inferred To

Nelfcd [nucleoplasm] (Mus musculus)

Nelfcd [nucleoplasm] (Rattus norvegicus)

nelfcd [nucleoplasm] (Danio rerio)

nelfcd [nucleoplasm] (Xenopus tropicalis)

TH1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of NELFCD [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of NELFCD [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NELFCD [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of NELFCD [nucleoplasm] (Sus scrofa)

NELFCD [nucleoplasm] (Bos taurus)

NELFCD [nucleoplasm] (Canis familiaris)

NELFCD [nucleoplasm] (Dictyostelium discoideum)

NELFCD [nucleoplasm] (Gallus gallus)

NELFCD [nucleoplasm] (Plasmodium falciparum)

NELFCD [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENSG00000101158, ENSP00000499018, ENST00000652272

OpenTargets

ENSG00000101158

GeneCards

NELFCD

HPA

ENSG00000101158-NELFCD

PRO

Q8IXH7

Pharos - Targets

Q8IXH7

GlyGen

Q8IXH7

PDB

5L3X, 8JJ6, 7YCX, 8W8E, 8UHA, 8UIS, 8UI0, 8UHG, 8UHD, 7PKS, 8RBX, 6GML

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.871	14
UniProt:A0A1U9X8X8 A0A1U9X8X8			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q8WX92-2 Q8WX922			0.556	3
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.553	5
UniProt:Q8WX92 NELFB	3	NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [nucleoplasm] (R-HSA-112427)	0.527	2
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.527	3

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