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P-TEFb complex [nucleoplasm]
Stable Identifier
R-HSA-112431
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV elongation arrest and recovery (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Abortive termination of HIV-1 elongation after arrest (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Pausing and recovery of HIV elongation (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
CDK12 stimulates expression of DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Formation of P-TEFb complex (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11884399
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA
Taube, R
,
Peterlin, BM
,
Fujinaga, K
,
Lin, X
J. Biol. Chem.
2002
Participants
components
CCNT1,CCNT2,CCNK [nucleoplasm]
(Homo sapiens)
CDK9 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
Formation of P-TEFb complex (Homo sapiens)
as an input of
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
as a member of
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
Inferred To
P-TEFb complex [nucleoplasm]
(Bos taurus)
P-TEFb complex [nucleoplasm]
(Caenorhabditis elegans)
P-TEFb complex [nucleoplasm]
(Canis familiaris)
P-TEFb complex [nucleoplasm]
(Danio rerio)
P-TEFb complex [nucleoplasm]
(Dictyostelium discoideum)
P-TEFb complex [nucleoplasm]
(Drosophila melanogaster)
P-TEFb complex [nucleoplasm]
(Gallus gallus)
P-TEFb complex [nucleoplasm]
(Mus musculus)
P-TEFb complex [nucleoplasm]
(Rattus norvegicus)
P-TEFb complex [nucleoplasm]
(Saccharomyces cerevisiae)
P-TEFb complex [nucleoplasm]
(Schizosaccharomyces pombe)
P-TEFb complex [nucleoplasm]
(Sus scrofa)
P-TEFb complex [nucleoplasm]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-222
,
CPX-322
,
CPX-321
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