TFIIS-mediated recovery of elongation from arrest

Stable Identifier
R-HSA-113413
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TFIIS-mediated recovery of elongation from arrest
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TFIIS reactivates arrested RNA Pol II directly interacting with the enzyme resulting in endonucleolytic excision of nascent transcript ~7-14 nucleotides upstream of the 3' end. This reaction is catalyzed by the catalytic site and results in the generation of a new 3'-OH terminus that could be used for re-extension from the correctly base paired site (reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Conaway, JW, Shilatifard, A, Conaway, RC

Annu Rev Biochem 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Bos taurus)
TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)
TFIIS-mediated recovery of elongation from arrest (Canis familiaris)
TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)
TFIIS-mediated recovery of elongation from arrest (Gallus gallus)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Mus musculus)
TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)
TFIIS-mediated recovery of elongation from arrest (Sus scrofa)
TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-06-23)
Created
Gopinathrao, G  (2004-05-07)
Cite Us!