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7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
Stable Identifier
R-HSA-113414
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. It is suggested that, arrest leads to extrusion of displaced transcripts 3'-end through the small pore near the Mg2+ ion. Pol II arrest may lead to abortive termination of elongation due to irreversible trapping of the 3'-end of the displaced transcript in the pore (reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID
Title
Journal
Year
12676794
The RNA polymerase II elongation complex.
Conaway, JW
,
Shilatifard, A
,
Conaway, RC
Annu Rev Biochem
2003
Participants
Input
Processive elongation complex [nucleoplasm]
(Homo sapiens)
Output
Arrested processive elongation complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Orthologous Events
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)
Authored
Gopinathrao, G (2004-06-23)
Created
Conaway, JW (2003-09-11)
Conaway, RC (2003-09-11)
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