Reactome | CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Stable Identifier

R-HSA-113824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chk2, Serine/threonine-protein kinase Chk2 (EC 2.7.1.-) (Cds1), Serine/threonine-protein kinase Chk2 , Cds1

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - CHEK2 is recruited to DNA DSBs (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)
      - Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - CHEK2 is recruited to DNA DSBs (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)
      - Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        CHEK2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O96017 CHEK2

Gene Names

CHEK2, CDS1, CHK2, RAD53

Chain

chain:1-543

Reference Genes

BioGPS Gene:11200 CHEK2

COSMIC (genes):CDS1 CHEK2

COSMIC (genes):CHEK2 CHEK2

CTD Gene:11200 CHEK2

dbSNP Gene:11200 CHEK2

ENSEMBL:ENSG00000183765 CHEK2

HGNC:16627 CHEK2

KEGG:hsa:11200 CHEK2

Monarch:11200 CHEK2

NCBI Gene:11200 CHEK2

OMIM:604373 CHEK2

UCSC:O96017 CHEK2

Reference Transcript

Other Identifiers

11200

11721893_a_at

11753669_x_at

11755467_x_at

16933502

210416_PM_s_at

210416_s_at

3582924

3582926

3658279

37887_at

3935863

3956445

3956448

3956449

3956450

3956451

3956452

3956453

3956454

3956456

3956457

3956458

3956459

3956460

3956461

3956464

3956465

3956466

3956467

3956468

3956469

3956470

3956471

3956472

3956473

3956474

3956475

3956476

3956477

3956478

3956480

3956482

3956483

8075164

A_23_P109452

A_33_P3386760

GE54748

GO:0000077

GO:0000086

GO:0000781

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0006281

GO:0006302

GO:0006355

GO:0006468

GO:0006629

GO:0006695

GO:0006914

GO:0006915

GO:0006974

GO:0006977

GO:0006978

GO:0007010

GO:0008630

GO:0010332

GO:0012501

GO:0016605

GO:0016740

GO:0019901

GO:0030163

GO:0031573

GO:0031625

GO:0042176

GO:0042770

GO:0042771

GO:0042802

GO:0042803

GO:0043226

GO:0044773

GO:0045893

GO:0046777

GO:0046872

GO:0050821

GO:0051301

GO:0070242

GO:0071480

GO:0090307

GO:0090399

GO:0106310

GO:0140096

GO:1901796

GO:2000785

HMNXSV003018841

HMNXSV003035313

HMNXSV003046320

ILMN_1759585

ILMN_2395236

ILMN_2395240

PH_hs_0008730

PH_hs_0032531

g13278893_3p_a_at

Participates

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)

as an input of

CHEK2 is recruited to DNA DSBs (Homo sapiens)

Other forms of this molecule

p-S,3T-CHEK2 [nucleoplasm]

p-T68-CHEK2 [nucleoplasm]

Inferred To

CHEK2 [nucleoplasm] (Bos taurus)

CHEK2 [nucleoplasm] (Canis familiaris)

CHEK2 [nucleoplasm] (Gallus gallus)

CHEK2 [nucleoplasm] (Mus musculus)

CHEK2 [nucleoplasm] (Rattus norvegicus)

CHEK2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_011528147.1, NP_009125.1, XP_016884050.1, NP_665861.1, NP_001005735.1, NP_001244316.1

ZINC - World Drugs

CHK2_HUMAN

Guide to Pharmacology - Targets

1988

OpenTargets

ENSG00000183765

ENSEMBL

ENSP00000496928, ENSP00000329012, ENST00000405598, ENST00000404276, ENST00000448511, ENST00000382580, ENST00000650281, ENST00000417588, ENSP00000404400, ENSP00000404567, ENST00000439346, ENSP00000396903, ENSP00000497000, ENSP00000372023, ENST00000348295, ENST00000649563, ENSP00000386087, ENST00000403642, ENSP00000412901, ENSP00000385747, ENST00000433728, ENSP00000390244, ENST00000425190, ENSP00000384919

ZINC - FDA approved

CHK2_HUMAN

ZINC - Substances

CHK2_HUMAN

ZINC - Biogenic

CHK2_HUMAN

ZINC target

O96017

PRO

O96017

GlyGen

O96017

PDB

2WTJ, 2W0J, 4BDJ, 2WTC, 4A9U, 2YCF, 2WTD, 2YCQ, 4A9R, 4BDA, 3I6U, 4A9S, 4BDB, 4BDK, 3VA4, 2YCR, 4BDC, 2YCS, 4BDD, 3I6W, 2YIQ, 4BDE, 2XM8, 2XM9, 2XBJ, 2YIR, 4BDF, 4BDG, 2XK9, 2YIT, 4BDH, 2CN5, 2WTI, 2CN8, 4A9T, 4BDI, 1GXC, 2W7X

ZINC - Investigational

CHK2_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000183765-CHEK2

Pharos - Targets

O96017

Orphanet

CHEK2

ZINC - Predictions - Purchasable

CHK2_HUMAN

HMDB Protein

HMDBP01248

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.733	7
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.72	7
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.719	6
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.66	6
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.658	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.646	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.645	8
UniProt:Q13362-3 PPP2R5C			0.633	4
UniProt:P30304 CDC25A	6	CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.623	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.602	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.602	3
UniProt:Q13362-1 PPP2R5C			0.602	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.59	2
UniProt:O15355 PPM1G			0.564	2
UniProt:P27958-PRO_0000037577			0.556	3
UniProt:Q96KN1 LRAT2			0.543	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.524	2
UniProt:Q9UQ88-1 CDK11A			0.524	2
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.508	2
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	3
UniProt:P0C6X7-PRO_0000037319 REP			0.508	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.508	3
UniProt:Q13362-2 PPP2R5C			0.508	2
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.508	3
UniProt:P06725 UL83	1	CMVPP65 [viral tegument] (R-HCY-5685583)	0.499	2
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.499	2
UniProt:P56645 PER3			0.499	2

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