Reactome | ORC1 [cytosol]

ORC1 [cytosol]

Stable Identifier

R-HSA-113840

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Orc1, Origin recognition complex subunit 1, Replication control protein 1

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External Reference Information

External Reference

UniProt:Q13415 ORC1

Gene Names

ORC1, ORC1L, PARC1

Chain

chain:1-861

Reference Genes

BioGPS Gene:4998 ORC1

COSMIC (genes):ORC1 ORC1

CTD Gene:4998 ORC1

dbSNP Gene:4998 ORC1

ENSEMBL:ENSG00000085840 ORC1

ENSEMBL_homo_sapiens_GENE:ENSG00000085840.13 ORC1

HGNC:8487 ORC1

KEGG Gene (Homo sapiens):4998 ORC1

Monarch:4998 ORC1

NCBI Gene:4998 ORC1

OMIM:601902 ORC1

UCSC:Q13415 ORC1

Reference Transcript

Other Identifiers

11727839_x_at

16687188

205085_PM_at

205085_at

2412800

2412801

2412802

2412803

2412804

2412805

2412807

2412809

2412810

2412811

2412812

2412813

2412814

2412815

2412818

2412819

2412820

2412822

2412823

2412824

2412825

2412826

2412827

2412829

2412830

2412831

2412833

38564_at

4998

7916167

A_23_P45799

GE59132

GO:0000166

GO:0000228

GO:0000278

GO:0000781

GO:0000808

GO:0003677

GO:0003682

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005829

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0023052

GO:0033314

GO:0043226

GO:0046872

GO:0140657

HMNXSV003053435

ILMN_1727459

PH_hs_0001609

TC01002658.hg

U40152_s_at

g4758849_3p_at

g4758849_3p_x_at

Participates

as an input of

ORC1 translocates to the nucleus (Homo sapiens)

Other forms of this molecule

ORC1 [nucleoplasm]

p-S,T-ORC1 [nucleoplasm]

PolyUb,p-S,T-ORC1 [nucleoplasm]

PolyUb,p-S,T-ORC1 [cytosol]

Inferred To

ORC1 [cytosol] (Bos taurus)

ORC1 [cytosol] (Canis familiaris)

ORC1 [cytosol] (Dictyostelium discoideum)

ORC1 [cytosol] (Drosophila melanogaster)

ORC1 [cytosol] (Gallus gallus)

ORC1 [cytosol] (Mus musculus)

ORC1 [cytosol] (Plasmodium falciparum)

ORC1 [cytosol] (Rattus norvegicus)

ORC1 [cytosol] (Saccharomyces cerevisiae)

ORC1 [cytosol] (Schizosaccharomyces pombe)

ORC1 [cytosol] (Sus scrofa)

orc1 [cytosol] (Xenopus tropicalis)

orc-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001177747.1, NP_001177748.1, NP_004144.2

OpenTargets

ENSG00000085840

GeneCards

Q13415

HPA

ENSG00000085840-ORC1

Ensembl

ENSG00000085840, ENSP00000360623, ENSP00000360621, ENST00000371566, ENST00000371568

PRO

Q13415

Pharos - Targets

Q13415

Orphanet

19843

PDB

7JPO, 7JPS, 5UJ7, 7CTF, 6P3W, 7JPP, 5UJM, 7CTG, 7JPR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.888	14
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.868	11
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.824	16
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.737	8
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.725	5
IntAct:EBI-15973242 H4(1129)			0.618	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:P03211 EBNA1			0.544	2
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.544	2
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.524	2

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