Reactome | BCL2L1 [mitochondrial outer membrane]

BCL2L1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-114236

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Apoptosis regulator Bcl-X, Bcl-2-like 1 protein

Locations in the PathwayBrowser for interactor UniProt:P45983 MAPK8

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External Reference Information

External Reference

UniProt:Q07817 BCL2L1

Gene Names

BCL2L1, BCL2L, BCLX

Chain

chain:1-233

Reference Genes

COSMIC (genes):BCL2L1 BCL2L1

dbSNP Gene:598 BCL2L1

ENSEMBL:ENSG00000171552 BCL2L1

Participates

as a component of

as an input of

as a member of

Bcl-2/Bcl-X(L) [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

BCL2L1 [cytosol]

Inferred To

BCL2L1 [mitochondrial outer membrane] (Bos taurus)

BCL2L1 [mitochondrial outer membrane] (Gallus gallus)

BCL2L1 [mitochondrial outer membrane] (Sus scrofa)

bcl2l1 [mitochondrial outer membrane] (Danio rerio)

bcl2l1 [mitochondrial outer membrane] (Xenopus tropicalis)

bcl-xL [mitochondrial outer membrane] (Canis familiaris)

Bcl2l1 [mitochondrial outer membrane] (Mus musculus)

Bcl2l1 [mitochondrial outer membrane] (Rattus norvegicus)

ced-9 [mitochondrial outer membrane] (Caenorhabditis elegans)

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.977	50
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.958	38
UniProt:Q13323 BIK			0.914	12
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.826	11
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.805	12
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.675	3
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.646	9
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.615	5
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.564	2
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:P22749 GNLY	2	GNLY [phagocytic vesicle lumen] (R-HSA-6807564) GNLY [extracellular region] (R-HSA-6806691)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q7Z5B4-5 RIC3			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P27469 G0S2	1	G0S2 [lipid droplet] (R-HSA-1989741)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.543	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.524	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.516	2
UniProt:Q9H2V7 SPNS1			0.463	3

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