Reactome | BCL2L1 [mitochondrial outer membrane]

BCL2L1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-114236

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Apoptosis regulator Bcl-X, Bcl-2-like 1 protein

Locations in the PathwayBrowser for interactor UniProt:Q92934 BAD

Expand all

External Reference Information

External Reference

UniProt:Q07817 BCL2L1

Gene Names

BCL2L1, BCL2L, BCLX

Chain

chain:1-233

Reference Genes

BioGPS Gene:598 BCL2L1

COSMIC (genes):BCL2L1 BCL2L1

CTD Gene:598 BCL2L1

dbSNP Gene:598 BCL2L1

ENSEMBL:ENSG00000171552 BCL2L1

ENSEMBL_homo_sapiens_GENE:ENSG00000171552.14 BCL2L1

HGNC:992 BCL2L1

KEGG Gene (Homo sapiens):598 BCL2L1

Monarch:598 BCL2L1

NCBI Gene:598 BCL2L1

OMIM:600039 BCL2L1

UCSC:Q07817 BCL2L1

Reference Transcript

Other Identifiers

11739957_a_at

11739958_x_at

11759514_at

1615_at

16918244

206665_PM_s_at

206665_s_at

212312_PM_at

212312_at

215037_PM_s_at

215037_s_at

231228_PM_at

231228_at

34742_at

3902490

3902491

3902492

3902493

3902522

3902523

3902524

3902525

3902526

3902527

3902528

3902529

3902530

3902531

3902532

598

65477_at

8065569

82590_at

A_23_P210886

A_24_P100130

GE60374

GE60550

GO:0000910

GO:0001541

GO:0001701

GO:0001836

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005759

GO:0005783

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006897

GO:0006914

GO:0006915

GO:0006950

GO:0007005

GO:0007281

GO:0007283

GO:0008584

GO:0008630

GO:0008637

GO:0009314

GO:0009566

GO:0009615

GO:0010507

GO:0012501

GO:0016020

GO:0016192

GO:0019901

GO:0022414

GO:0023052

GO:0030154

GO:0030672

GO:0031410

GO:0031965

GO:0031966

GO:0032465

GO:0032946

GO:0034097

GO:0035234

GO:0040008

GO:0042802

GO:0042803

GO:0042981

GO:0043066

GO:0043226

GO:0043524

GO:0044565

GO:0045202

GO:0046898

GO:0046902

GO:0046982

GO:0048856

GO:0050673

GO:0051093

GO:0051402

GO:0051434

GO:0051607

GO:0051881

GO:0061024

GO:0071230

GO:0071312

GO:0071480

GO:0071839

GO:0072659

GO:0090201

GO:0097048

GO:0097136

GO:0097192

GO:0097284

GO:0098542

GO:1900118

GO:1901029

GO:1902042

GO:1902230

GO:1902236

GO:1903077

GO:2000242

GO:2000669

GO:2000811

GO:2001233

GO:2001240

GO:2001243

HMNXSV003013398

HMNXSV003029432

Hs.143912.0.A1_3p_at

Hs.305890.1.S1_3p_at

Hs.305890.2.S1_3p_a_at

ILMN_1654118

ILMN_1742410

PH_hs_0015713

TC20000756.hg

TC20001531.hg

Z23115_at

g4502380_3p_a_at

Participates

as a component of

as an input of

as a member of

Bcl-2/Bcl-X(L) [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

BCL2L1 [cytosol]

Inferred To

BCL2L1 [mitochondrial outer membrane] (Bos taurus)

BCL2L1 [mitochondrial outer membrane] (Gallus gallus)

BCL2L1 [mitochondrial outer membrane] (Sus scrofa)

bcl2l1 [mitochondrial outer membrane] (Danio rerio)

bcl2l1 [mitochondrial outer membrane] (Xenopus tropicalis)

bcl-xL [mitochondrial outer membrane] (Canis familiaris)

Bcl2l1 [mitochondrial outer membrane] (Mus musculus)

Bcl2l1 [mitochondrial outer membrane] (Rattus norvegicus)

ced-9 [mitochondrial outer membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001182.1, NP_001309168.1, NP_001309171.1, XP_016883482.1, NP_001304850.1, NP_612815.1, NP_001309169.1, NP_001304848.1, XP_011527266.1, NP_001304849.1

Guide to Pharmacology - Targets

2845

OpenTargets

ENSG00000171552

ZINC - Substances

B2CL1_HUMAN

ZINC - Biogenic

B2CL1_HUMAN

ZINC target

Q07817

PRO

Q07817

PDB

1YSG, 4QVE, 5FMJ, 4C52, 3ZLN, 3SP7, 3ZLR, 6ST2, 1YSI, 1BXL, 6UVC, 2YQ6, 2PON, 4QVF, 1YSN, 2YXJ, 5FMK, 4BPK, 2YQ7, 4QVX, 6ZHC, 1R2H, 4HNJ, 2YJ1, 6UVF, 3PL7, 6O0K, 8U27, 8IQK, 2O2M, 5AGW, 3INQ, 3FDM, 2O2N, 6UVH, 8XP5, 5VAY, 4A1U, 6DCN, 7XGF, 6O0M, 6O0L, 7LH7, 4AQ3, 4IEH, 6O0P, 3R85, 6UVE, 3CVA, 6RNU, 6YLI, 6O0O, 6DCO, 6VWC, 3QKD, 2M03, 1MAZ, 1R2I, 8IQL, 4PPI, 7JGW, 5AGX, 7JGV, 3ZLO, 4C5D, 4CIN, 8WLS, 6HJL, 5C3G, 6BF2, 6X7I, 2O1Y, 3SPF, 1R2E, 5B1Z, 1LXL, 2M04, 4EHR, 6F46, 2LP8, 3FDL, 3ZK6, 4TUH, 3IO8, 8FY0, 2B48, 2ME8, 7Y8D, 2LPC, 2ME9, 7CA4, 1R2D, 4A1W, 1G5J, 3WIZ, 6IJQ, 1R2G, 6LHD, 7XGG, 6UVD, 6UVG, 2P1L, 4Z9V, 5VX3, 7YAA, 2MEJ

ZINC - Investigational

B2CL1_HUMAN

ZINC - Metabolites

B2CL1_HUMAN

GeneCards

Q07817

HPA

ENSG00000171552-BCL2L1

Ensembl

ENSP00000365230, ENSP00000411252, ENST00000456404, ENSP00000395545, ENSP00000389688, ENSP00000401173, ENST00000439267, ENST00000676942, ENST00000677194, ENSP00000365223, ENST00000678563, ENSP00000504387, ENSP00000503725, ENST00000376062, ENST00000420488, ENSG00000171552, ENSP00000504536, ENST00000676582, ENST00000434194, ENST00000422920, ENSP00000504237, ENSP00000302564, ENST00000307677, ENSP00000390760, ENST00000376055

Pharos - Targets

Q07817

ZINC - Predictions - Purchasable

B2CL1_HUMAN

Orphanet

25595

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.977	50
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.958	38
UniProt:Q13323 BIK			0.914	12
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.826	11
UniProt:Q96LC9 BMF	3	p-BMF [mitochondrial outer membrane] (R-HSA-3145026) BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529)	0.805	12
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.675	3
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.646	9
UniProt:Q07812 BAX	3	BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907) BAX [mitochondrial outer membrane] (R-HSA-139949)	0.615	5
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.564	2
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:P22749 GNLY	2	GNLY [phagocytic vesicle lumen] (R-HSA-6807564) GNLY [extracellular region] (R-HSA-6806691)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q7Z5B4-5 RIC3			0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P27469 G0S2	1	G0S2 [lipid droplet] (R-HSA-1989741)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.543	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.524	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.516	2
UniProt:Q9H2V7 SPNS1			0.463	3

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