Reactome | Release of Cytochrome c from mitochondria

Release of Cytochrome c from mitochondria

Stable Identifier

R-HSA-114284

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

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Release of Cytochrome c from mitochondria

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Permeabilization of the outer mitochondrial membrane by pro-apoptotic BCL2 family proteins, such as BAK and BAX, allows cytochrome c eflux from the mitochondrial intermembrane space into the cytosol (Arnoult et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12660240	Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. Song, Z, Yao, X, Wu, M	J Biol Chem	2003
12941691	Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. Arnoult, D, Gaume, B, Karbowski, M, Sharpe, JC, Cecconi, F, Youle, RJ	EMBO J	2003

Participants

Input

CYCS [mitochondrial intermembrane space] (Homo sapiens)

Output

CYCS [cytosol] (Homo sapiens)

Participates

as an event of

This event is regulated

Positively by

Regulator

GSDME:cardiolipin [mitochondrial outer membrane] (Homo sapiens)

Active Unit

GSDME(1-270) [cytosol]

Regulator

Activated BAX,BAK oligomers [mitochondrial outer membrane] (Homo sapiens)

Regulator

GSDMD(1-275):cardiolipin [mitochondrial outer membrane] (Homo sapiens)

Active Unit

GSDMD(1-275) [cytosol]

Orthologous Events

Release of Cytochrome c from mitochondria (Bos taurus)

Release of Cytochrome c from mitochondria (Caenorhabditis elegans)

Release of Cytochrome c from mitochondria (Canis familiaris)

Release of Cytochrome c from mitochondria (Danio rerio)

Release of Cytochrome c from mitochondria (Dictyostelium discoideum)

Release of Cytochrome c from mitochondria (Drosophila melanogaster)

Release of Cytochrome c from mitochondria (Gallus gallus)

Release of Cytochrome c from mitochondria (Mus musculus)

Release of Cytochrome c from mitochondria (Plasmodium falciparum)

Release of Cytochrome c from mitochondria (Rattus norvegicus)

Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)

Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)

Release of Cytochrome c from mitochondria (Sus scrofa)

Release of Cytochrome c from mitochondria (Xenopus tropicalis)

Reviewed

Matthews, L (2018-09-25)

Kanneganti, TD (2021-02-17)

D'Eustachio, P (2021-02-17)

Shao, F (2021-04-22)

Created

Alnemri, E (2004-02-17)

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