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STX4 [cytosol]
Stable Identifier
R-HSA-114505
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Syntaxin 4
Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Disinhibition of SNARE formation (Homo sapiens)
Phosphorylation of Syntaxin-4 (Homo sapiens)
STX4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12846 STX4
Gene Names
STX4, STX4A
Chain
chain:1-297
Reference Genes
BioGPS Gene:6810 STX4
COSMIC (genes):STX4 STX4
CTD Gene:6810 STX4
dbSNP Gene:6810 STX4
ENSEMBL:ENSG00000103496 STX4
HGNC:11439 STX4
KEGG:hsa:6810 STX4
Monarch:6810 STX4
NCBI Gene:6810 STX4
OMIM:186591 STX4
UCSC:Q12846 STX4
Reference Transcript
RefSeq:NM_004604.4 STX4
RefSeq:NM_001272096.1 STX4
Other Identifiers
11725677_a_at
16818125
16818147
203530_PM_s_at
203530_s_at
229395_PM_at
229395_at
236232_PM_at
236232_at
3656761
3656762
3656763
3656764
3656765
3656766
3656767
3656768
3656769
3656770
3656771
3656772
3656773
3656774
3656775
3656776
3656777
3656778
3656779
3656780
3656781
3656782
3656784
3656786
3656787
3656789
3656791
37911_at
61844_at
6810
7995017
91166_at
A_23_P256375
GE58889
GE814894
GO:0000149
GO:0000322
GO:0002639
GO:0005484
GO:0005515
GO:0005615
GO:0005737
GO:0005768
GO:0005773
GO:0005802
GO:0005829
GO:0005886
GO:0006836
GO:0006886
GO:0006887
GO:0006906
GO:0007605
GO:0008284
GO:0009986
GO:0012505
GO:0016020
GO:0016192
GO:0016230
GO:0016323
GO:0017157
GO:0030027
GO:0030335
GO:0030670
GO:0031201
GO:0031410
GO:0032420
GO:0032589
GO:0034394
GO:0034599
GO:0035493
GO:0035749
GO:0035774
GO:0036477
GO:0042581
GO:0042995
GO:0043085
GO:0043197
GO:0043219
GO:0043226
GO:0043311
GO:0045202
GO:0045335
GO:0045785
GO:0048278
GO:0048284
GO:0048471
GO:0050877
GO:0050921
GO:0060090
GO:0060291
GO:0061024
GO:0065003
GO:0070062
GO:0071346
GO:0098685
GO:0098772
GO:0098794
GO:0098978
GO:0099072
GO:1902041
GO:1903078
GO:1903575
GO:2000010
HMNXSV003048655
HMNXSV003055143
Hs.145038.0.A1_3p_at
Hs.83734.1.S1_3p_at
ILMN_1680313
PH_hs_0004775
PH_hs_0008606
TC16000366.hg
TC16001493.hg
U07158_at
g4759185_3p_a_at
Participates
as an input of
Phosphorylation of Syntaxin-4 (Homo sapiens)
Other forms of this molecule
STX4 [plasma membrane]
STX4 [phagocytic vesicle membrane]
p-STX4 [cytosol]
Inferred To
SSO2 [cytosol]
(Saccharomyces cerevisiae)
stx4 [cytosol]
(Danio rerio)
stx4 [cytosol]
(Xenopus tropicalis)
STX4 [cytosol]
(Bos taurus)
STX4 [cytosol]
(Canis familiaris)
STX4 [cytosol]
(Plasmodium falciparum)
STX4 [cytosol]
(Sus scrofa)
syn1A [cytosol]
(Dictyostelium discoideum)
syx-2 [cytosol]
(Caenorhabditis elegans)
unc-64 [cytosol]
(Caenorhabditis elegans)
Homologues of STX4 [cytosol]
(Caenorhabditis elegans)
Homologues of STX4 [cytosol]
(Dictyostelium discoideum)
Homologues of STX4 [cytosol]
(Saccharomyces cerevisiae)
syn1B [cytosol]
(Dictyostelium discoideum)
psy1 [cytosol]
(Schizosaccharomyces pombe)
Syx1A [cytosol]
(Drosophila melanogaster)
Stx4 [cytosol]
(Mus musculus)
Stx4 [cytosol]
(Rattus norvegicus)
SSO1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_004595.2
,
NP_001259025.1
OpenTargets
ENSG00000103496
ENSEMBL
ENSP00000378447
,
ENSP00000317714
,
ENST00000394998
,
ENST00000313843
HPA
ENSG00000103496-STX4
PRO
Q12846
Pharos - Targets
Q12846
GlyGen
Q12846
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.884
10
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.871
9
UniProt:Q86Y82 STX12
0.871
9
UniProt:O95183 VAMP5
0.832
9
UniProt:O15400 STX7
0.831
9
UniProt:O75379 VAMP4
4
VAMP4 [transport vesicle]
(R-HSA-6811023)
VAMP4 [trans-Golgi network membrane]
(R-HSA-6811021)
VAMP4 [plasma membrane]
(R-HSA-8864461)
VAMP4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869133)
0.831
8
UniProt:Q13277 STX3
1
STX3 [plasma membrane]
(R-HSA-449131)
0.83
8
UniProt:Q9UNK0 STX8
0.782
8
UniProt:Q53TN4 CYBRD1
1
CYBRD1 [plasma membrane]
(R-HSA-917788)
0.781
7
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.779
5
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.718
6
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.718
6
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
0.718
6
UniProt:Q13190 STX5
5
STX5 [cytosol]
(R-HSA-9613991)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
0.718
6
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.718
6
UniProt:Q96IW7 SEC22A
3
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.718
6
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.718
6
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.675
4
UniProt:O75379-2 VAMP4
0.666
4
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.602
4
UniProt:P32856-2 STX2
0.601
4
UniProt:P23763-3 VAMP1
0.556
3
UniProt:O60499-2 STX10
0.556
3
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.556
3
UniProt:Q8TGQ7 YP159
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q969S6 TM203
0.556
3
UniProt:Q5SQN1 SNP47
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.556
3
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:Q9Y6X1 SERP1
2
SERP1 [endoplasmic reticulum membrane]
(R-HSA-381045)
SERP1 [cytosol]
(R-HSA-5250574)
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
3
UniProt:Q08144
1
TLG2 [trans-Golgi network membrane]
(R-SCE-6811002)
0.556
3
UniProt:Q96IV6 FXDC2
0.556
3
UniProt:O14662 STX16
2
STX16 [Golgi membrane]
(R-HSA-6811001)
STX16 [trans-Golgi network membrane]
(R-HSA-6811002)
0.556
3
UniProt:O95159 ZFPL1
0.556
3
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.556
3
UniProt:O14662-5 STX16
0.556
3
UniProt:P61266 STX1B
3
STX1B(1-?) [cytosol]
(R-HSA-5246520)
STX1B(?-288) [plasma membrane]
(R-HSA-5246519)
STX1B [plasma membrane]
(R-HSA-181479)
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q8N511 TM199
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:P38736
1
GOS1 [Golgi membrane]
(R-SCE-6807753)
0.556
3
UniProt:P60201-2 PLP1
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:P23763 VAMP1
7
VAMP1(84-118) [synaptic vesicle membrane]
(R-HSA-5250991)
VAMP1(1-83) [cytosol]
(R-HSA-5250967)
VAMP1(1-61) [cytosol]
(R-HSA-2976003)
VAMP1(62-118) [synaptic vesicle membrane]
(R-HSA-5250599)
VAMP1(1-60) [cytosol]
(R-HSA-2976004)
VAMP1(61-118) [synaptic vesicle membrane]
(R-HSA-5250888)
VAMP1 [synaptic vesicle membrane]
(R-HSA-2976040)
0.556
3
UniProt:P25385
4
BOS1 [Golgi membrane]
(R-SCE-6807755)
BOS1 [ER to Golgi transport vesicle membrane]
(R-SCE-5689800)
BOS1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-SCE-535472)
BOS1 [endoplasmic reticulum membrane]
(R-SCE-5689451)
0.556
3
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
UniProt:O76038 SEGN
0.527
2
UniProt:P25103 TACR1
2
TACR1 [plasma membrane]
(R-HSA-380103)
TACR1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869122)
0.527
2
UniProt:O95858 TSPAN15
2
TSPAN15 [plasma membrane]
(R-HSA-9010043)
TSPAN15 [endoplasmic reticulum lumen]
(R-HSA-9010117)
0.527
2
UniProt:Q3MIR4 CC50B
0.527
2
UniProt:O00186 STXBP3
4
p-Y521-STXBP3 [plasma membrane]
(R-HSA-2263472)
STXBP3 [plasma membrane]
(R-HSA-2263473)
p-STXBP3 [cytosol]
(R-HSA-114680)
STXBP3 [cytosol]
(R-HSA-114682)
0.527
2
UniProt:Q7Z602 GP141
0.527
2
UniProt:Q8TBJ4 PLPPR1
1
LPPR1 [plasma membrane]
(R-HSA-6797625)
0.527
2
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.527
2
UniProt:Q6PD74 AAGAB
0.527
2
UniProt:Q12797 ASPH
2
ASPH [endoplasmic reticulum lumen]
(R-HSA-9631383)
ASPH [endoplasmic reticulum membrane]
(R-HSA-5490331)
0.527
3
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
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