Reactome | RAC1,RAC2,RHOG activate PI3K

RAC1,RAC2,RHOG activate PI3K

Stable Identifier

R-HSA-114542

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References

PubMed ID	Title	Journal	Year
11803464	Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB Murga, C, Teramoto, H, Zohar, M, Gutkind, JS	Oncogene	2002
8645157	Rac GTPase interacts specifically with phosphatidylinositol 3-kinase Knaus, UG, Wang, Y, Bokoch, GM, Traynor-Kaplan, AE, Vlahos, CJ	Biochem J	1996
7744773	Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation Hartwig, JH, Cantley, LC, Toker, A, Bachelot, C, Duckworth, B, Vlahos, CJ, Kovacsovics, TJ	J Biol Chem	1995