p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004).
Siderovski, DP, Willard, FS
Fukuhara, S, Gutkind, JS, Chikumi, H
Guo, L, Chen, Z, Gutowski, S, Hadas, J, Sternweis, PC, Sprang, SR
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