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PECAM1 [plasma membrane]
Stable Identifier
R-HSA-114686
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PECAM-1, Platelet endothelial cell adhesion molecule precursor, CD31 antigen, EndoCAM, GPIIA'
Icon
Locations in the PathwayBrowser for interactor UniProt:Q99619 SPSB2
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
PECAM1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
CD177 binds PECAM-1 (Homo sapiens)
PECAM1 [plasma membrane] (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
PECAM1 [plasma membrane] (Homo sapiens)
Trans-homophilic interaction of PECAM-1 (Homo sapiens)
PECAM1 [plasma membrane] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM1 is phosphorylated (Homo sapiens)
PECAM1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16284 PECAM1
Gene Names
PECAM1
Chain
signal peptide:1-27, chain:28-738
Reference Genes
BioGPS Gene:5175 PECAM1
COSMIC (genes):PECAM1 PECAM1
CTD Gene:5175 PECAM1
dbSNP Gene:5175 PECAM1
ENSEMBL:ENSG00000261371 PECAM1
ENSEMBL_homo_sapiens_GENE:ENSG00000261371.6 PECAM1
HGNC:8823 PECAM1
KEGG Gene (Homo sapiens):5175 PECAM1
Monarch:5175 PECAM1
NCBI Gene:5175 PECAM1
OMIM:173445 PECAM1
Reference Transcript
RefSeq:XM_005276881.1 PECAM1
RefSeq:XM_017024740.1 PECAM1
RefSeq:XM_017024738.1 PECAM1
RefSeq:XM_005276882.1 PECAM1
RefSeq:NM_000442.4 PECAM1
RefSeq:XM_017024739.1 PECAM1
RefSeq:XM_011524889.2 PECAM1
RefSeq:XM_005276880.1 PECAM1
RefSeq:XM_011524890.1 PECAM1
Other Identifiers
11720644_a_at
11757545_x_at
1558397_PM_at
1558397_at
17125960
208981_PM_at
208981_at
208982_PM_at
208982_at
208983_PM_s_at
208983_s_at
268_at
37398_at
3766798
3766799
3766800
3766801
3766802
3766803
3766804
3766805
3766806
3766807
3766819
3766824
3766825
3766828
3766829
3766830
3766831
3766833
3766834
3766835
3766838
3766841
3766847
3766848
3766849
3766850
3766851
47482_at
5175
8017599
90067_s_at
A_33_P3229402
A_33_P3405213
GE60495
GE778494
GO:0001934
GO:0002376
GO:0004888
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005911
GO:0006909
GO:0007155
GO:0007156
GO:0007159
GO:0007165
GO:0007166
GO:0008037
GO:0016020
GO:0016192
GO:0023052
GO:0030154
GO:0030335
GO:0030667
GO:0031092
GO:0031410
GO:0032991
GO:0034330
GO:0035633
GO:0035696
GO:0036211
GO:0042803
GO:0043226
GO:0045121
GO:0048856
GO:0048870
GO:0050731
GO:0050904
GO:0060089
GO:0061028
GO:0070062
GO:0070161
GO:0070830
GO:0072011
GO:0072672
GO:0098609
GO:0098742
GO:0150107
HMNXSV003027445
HMNXSV003057981
Hs.78146.0.S2_3p_at
Hs.78146.0.S3_3p_at
Hs2.376675.1.S1_3p_at
ILMN_1689518
L34657_at
PH_hs_0004514
PH_hs_0018325
TC17001798.hg
TC17002747.hg
X96849_at
g187239_3p_a_at
Participates
as a member of
Platelet alpha granule membrane components that are released on degranulation [plasma membrane] (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
PECAM1 dimer [plasma membrane] (Homo sapiens)
PECAM1:CD177 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:PECAM1 [plasma membrane] (Homo sapiens)
as an input of
Trans-homophilic interaction of PECAM-1 (Homo sapiens)
PECAM1 is phosphorylated (Homo sapiens)
CD177 binds PECAM-1 (Homo sapiens)
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
Other forms of this molecule
PECAM1 [platelet alpha granule membrane]
PECAM1 [secretory granule membrane]
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
p-Y713-PECAM1 [plasma membrane]
Inferred To
Pecam1 [plasma membrane]
(Mus musculus)
Pecam1 [plasma membrane]
(Rattus norvegicus)
Homologues of PECAM1 [plasma membrane]
(Sus scrofa)
PECAM1 [plasma membrane]
(Bos taurus)
PECAM1 [plasma membrane]
(Canis familiaris)
PECAM1 [plasma membrane]
(Gallus gallus)
PECAM1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016880229.1
,
NP_000433.4
,
XP_016880227.1
,
XP_005276937.1
,
XP_005276939.1
,
XP_005276938.1
,
XP_011523191.1
,
XP_011523192.1
,
XP_016880228.1
OpenTargets
ENSG00000261371
HPA
ENSG00000261371-PECAM1
GeneCards
P16284
Ensembl
ENSP00000457421
,
ENST00000563924
,
ENSG00000261371
PRO
P16284
Pharos - Targets
P16284
PDB
5GNI
,
5C14
,
2KY5
Interactors (83)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.69
7
UniProt:P09382 LGALS1
2
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
0.675
4
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.61
7
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.59
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.556
3
IntAct:EBI-25881637 CCSB
0.556
3
UniProt:Q9NX09 DDIT4
1
DDIT4 [cytosol]
(R-HSA-5632374)
0.556
3
UniProt:Q8NCS7 SLC44A5
1
SLC44A5 [plasma membrane]
(R-HSA-444459)
0.556
3
UniProt:Q6ZSB9 ZBT49
0.556
3
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.556
3
UniProt:Q08AE8 SPIR1
0.556
3
IntAct:EBI-25861394 CCSB
0.556
3
UniProt:Q6ZU52 K0408
0.556
3
UniProt:Q9GZQ6 NPFFR1
1
NPFFR1 [plasma membrane]
(R-HSA-389429)
0.556
3
UniProt:Q9UJD0 RIMS3
0.556
3
UniProt:Q9HB63 NTN4
1
NTN4 [plasma membrane]
(R-HSA-561258)
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
IntAct:EBI-25881483 CCSB
0.556
3
UniProt:Q9H270 VPS11
1
VPS11 [endosome membrane]
(R-HSA-2197802)
0.556
3
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.556
3
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.556
3
UniProt:Q8N302-2 Q8N3022
0.556
3
UniProt:Q96LI6 HSFY1
0.556
3
UniProt:Q9UMX3 BOK
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q6ZQX7-4 Q6ZQX74
0.556
3
UniProt:Q8WUY3 PRUN2
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.556
3
UniProt:P12757 SKIL
1
SKIL [nucleoplasm]
(R-HSA-2186596)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1 [nucleoplasm]
(R-HSA-6803472)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
0.556
3
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:Q6DHV7-2 Q6DHV72
0.556
3
UniProt:Q96G97-4 BSCL2
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P61966-2 AP1S1
0.556
3
UniProt:P61513 RPL37A
1
RPL37A [cytosol]
(R-HSA-72468)
0.556
3
UniProt:Q96GL9 F163A
0.556
3
UniProt:Q14847-2 LASP1
0.556
3
UniProt:P54819 AK2
1
AK2 [mitochondrial intermembrane space]
(R-HSA-57822)
0.556
3
UniProt:O77932 DXO
0.556
3
UniProt:P19544-6 WT1
0.556
3
UniProt:O75874 IDH1
10
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:Q12824 SMARCB1
1
SMARCB1 [nucleoplasm]
(R-HSA-389261)
0.556
3
UniProt:Q8NC51 SERB1
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:Q5VYS8-5 TUT7
0.556
3
UniProt:Q5T1C6 THEM4
3
THEM4 [mitochondrial matrix]
(R-HSA-162408)
THEM4 [cytosol]
(R-HSA-6809345)
THEM4 [plasma membrane]
(R-HSA-199437)
0.556
3
UniProt:Q14728 MFS10
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q16549 PCSK7
0.556
3
UniProt:Q96HB5 CC120
0.556
3
UniProt:Q99619 SPSB2
1
SPSB2 [cytosol]
(R-HSA-976048)
0.556
3
UniProt:Q9H7C4 SYNCI
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:Q4G1C9-2 Q4G1C92
0.556
3
UniProt:Q99504 EYA3
2
p-EYA3 [nucleoplasm]
(R-HSA-5683979)
EYA3 [nucleoplasm]
(R-HSA-5683622)
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:Q7Z403 TMC6
3
TMC6 [tertiary granule membrane]
(R-HSA-6800920)
TMC6 [plasma membrane]
(R-HSA-6800446)
TMC6 [specific granule membrane]
(R-HSA-6799712)
0.556
3
UniProt:Q5JSH3 WDR44
0.556
3
UniProt:P15923-3 TCF3
0.556
3
UniProt:I6L9F6 I6L9F6
0.556
3
UniProt:Q7Z614-3 SNX20
0.556
3
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.556
3
UniProt:Q13428-5 TCOF1
0.556
3
UniProt:Q8TBJ4 PLPPR1
1
LPPR1 [plasma membrane]
(R-HSA-6797625)
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q13405 MRPL49
1
MRPL49 [mitochondrial inner membrane]
(R-HSA-5368260)
0.556
3
UniProt:P26651 ZFP36
2
p-S60,S186-ZFP36 [cytosol]
(R-HSA-450496)
ZFP36 [cytosol]
(R-HSA-450562)
0.556
3
UniProt:Q96E93 KLRG1
1
KLRG1 [plasma membrane]
(R-HSA-198006)
0.556
3
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
0.556
3
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.483
3
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.462
4
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