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THBS1 [platelet alpha granule lumen]
Stable Identifier
R-HSA-114701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Thrombospondin 1 precursor
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
THBS1 trimer [platelet alpha granule lumen] (Homo sapiens)
THBS1 [platelet alpha granule lumen] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
THBS1 trimer [platelet alpha granule lumen] (Homo sapiens)
THBS1 [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07996 THBS1
Gene Names
THBS1, TSP, TSP1
Chain
signal peptide:1-18, chain:19-1170
Reference Genes
BioGPS Gene:7057 THBS1
COSMIC (genes):THBS1 THBS1
CTD Gene:7057 THBS1
dbSNP Gene:7057 THBS1
ENSEMBL:ENSG00000137801.11 THBS1
HGNC:11785 THBS1
KEGG Gene (Homo sapiens):7057 THBS1
Monarch:7057 THBS1
NCBI Gene:7057 THBS1
OMIM:188060 THBS1
UCSC:P07996 THBS1
Reference Transcript
RefSeq:NM_003246.3 THBS1
Other Identifiers
0004480278
115_at
11721090_at
11721091_a_at
11721092_a_at
11721093_a_at
11758842_at
16799315
201107_PM_s_at
201107_s_at
201108_PM_s_at
201108_s_at
201109_PM_s_at
201109_s_at
201110_PM_s_at
201110_s_at
235086_PM_at
235086_at
3589467
3589468
3589469
3589470
3589472
3589473
3589474
3589475
3589479
3589482
3589484
3589486
3589487
3589489
3589491
3589493
3589495
3589497
3589498
3589500
3589501
3589504
3589505
3589509
3589510
3589511
3589512
3589513
3589514
3589515
3589516
53546_at
7057
7982597
867_s_at
A_14_P135563
A_23_P206212
A_33_P3415820
GE81252
GE86195
GO:0001666
GO:0001786
GO:0001937
GO:0001953
GO:0001968
GO:0002040
GO:0002376
GO:0002544
GO:0002581
GO:0002605
GO:0005178
GO:0005198
GO:0005201
GO:0005509
GO:0005515
GO:0005576
GO:0005577
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0006954
GO:0006955
GO:0006986
GO:0007155
GO:0008201
GO:0008284
GO:0008285
GO:0008289
GO:0009410
GO:0009612
GO:0009749
GO:0009897
GO:0009986
GO:0010595
GO:0010596
GO:0010748
GO:0010751
GO:0010754
GO:0010757
GO:0010759
GO:0010763
GO:0012501
GO:0016192
GO:0016477
GO:0016525
GO:0016529
GO:0017134
GO:0018149
GO:0023052
GO:0030141
GO:0030169
GO:0030194
GO:0030312
GO:0030335
GO:0030511
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0032026
GO:0032570
GO:0032695
GO:0032760
GO:0032914
GO:0032991
GO:0033574
GO:0034330
GO:0034605
GO:0034976
GO:0036211
GO:0040037
GO:0042060
GO:0042327
GO:0042802
GO:0043032
GO:0043066
GO:0043154
GO:0043226
GO:0043236
GO:0043394
GO:0043406
GO:0043536
GO:0043537
GO:0043652
GO:0045727
GO:0045766
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0050431
GO:0050840
GO:0050921
GO:0051592
GO:0051604
GO:0051895
GO:0051897
GO:0051918
GO:0055085
GO:0061024
GO:0062023
GO:0070051
GO:0070052
GO:0070062
GO:0071356
GO:0071363
GO:0071636
GO:0090051
GO:1902043
GO:1903588
GO:1903671
GO:2000353
GO:2000379
GO:2001027
GO:2001237
HMNXSV003024540
Hs.42699.0.A1_3p_at
Hs.87409.0.A1_3p_a_at
Hs.87409.0.A2_3p_a_at
Hs.87409.0.A3_3p_a_at
ILMN_1686116
PH_hs_0022773
TC15000270.hg
X14787_at
g4507484_3p_a_at
Participates
as a component of
THBS1 trimer [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
THBS1 [endoplasmic reticulum lumen]
glc-fuc-THBS1 [endoplasmic reticulum lumen]
O-fuc-THBS1 [endoplasmic reticulum lumen]
THBS1 [extracellular region]
Inferred To
thbs1 [platelet alpha granule lumen]
(Xenopus tropicalis)
THBS1 [platelet alpha granule lumen]
(Bos taurus)
THBS1 [platelet alpha granule lumen]
(Canis familiaris)
THBS1 [platelet alpha granule lumen]
(Danio rerio)
THBS1 [platelet alpha granule lumen]
(Gallus gallus)
THBS1 [platelet alpha granule lumen]
(Sus scrofa)
Homologues of THBS1 [platelet alpha granule lumen]
(Drosophila melanogaster)
Thbs1 [platelet alpha granule lumen]
(Mus musculus)
Thbs1 [platelet alpha granule lumen]
(Rattus norvegicus)
Dmel\CG9297 [platelet alpha granule lumen]
(Drosophila melanogaster)
Tsp [platelet alpha granule lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003237.2
OpenTargets
ENSG00000137801
GeneCards
P07996
HPA
ENSG00000137801-THBS1
Ensembl
ENST00000260356
,
ENSG00000137801
,
ENSP00000260356
PRO
P07996
Pharos - Targets
P07996
PDB
1UX6
,
1ZA4
,
2ERF
,
2OUH
,
1Z78
,
5FOE
,
2ES3
,
3R6B
,
2OUJ
,
1LSL
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:18376 DERMATAN
0.609
2
ChEBI:28304 HEPARIN
0.609
3
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.609
2
heparan sulfate [ChEBI:28815]
1
HS [extracellular region]
(R-ALL-190915)
0.609
2
UniProt:Q15113 PCOLCE
1
PCOLCE [extracellular region]
(R-HSA-2002444)
0.558
3
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.525
2
UniProt:P08567 PLEK
2
PLEK [extracellular region]
(R-HSA-350741)
PLEK [cytosol]
(R-HSA-350715)
0.462
3
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