Reactome | PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

Stable Identifier

R-HSA-1168373

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Protein Kinase C beta (PKC-beta, PRKCB) is activated

ReviewStatus

5/5

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PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

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Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8387275	Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate Hummel, R, Marmé, D, Sarre, TF, Fiebich, B, Hug, H, Kochs, G	Biochem J	1993
12118249	PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling Patrone, L, Teitell, M, Kang, S, Kawakami, Y, Kawakami, T, Kato, RM, Sommer, K, Humphries, LA, Leitges, M, Chae, K, Rawlings, DJ, Guo, B, Su, TT, Wall, R	Nat Immunol	2002
12070292	Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha Mecklenbräuker, I, Saijo, K, Schmedt, C, Tarakhovsky, A, Leitger, M, Santana, A	J Exp Med	2002
8670417	Immunodeficiency in protein kinase cbeta-deficient mice Stabel, S, Schmedt, C, Leitges, M, Tarakhovsky, A, Davoust, J, Guinamard, R, Schaal, S	Science	1996