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(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
Stable Identifier
R-HSA-1168601
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SCF-beta-TrCp1,2, SCF-beta-TrCp1 or SCF-beta-TrCP2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22045853
Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1
Shi, Y
,
Shi, P
,
Liu, Y
,
Liu, Y
,
Chen, Z
,
Zhu, S
,
Qian, Y
,
Lin, Y
Sci Signal
2011
Participants
members
BTRC:CUL1:SKP1 [cytosol]
(Homo sapiens)
CUL1:FBXW11:SKP1 [cytosol]
(Homo sapiens)
Participates
as an input of
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
as an output of
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
as a component of
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Inferred To
BTRC:CUL1:SKP1 [cytosol]
(Xenopus tropicalis)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
(Rattus norvegicus)
Ghost homologue of (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
(Danio rerio)
Ghost homologue of (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
(Drosophila melanogaster)
Ghost homologue of (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
(Sus scrofa)
CUL1:FBXW11:SKP1 [cytosol]
(Bos taurus)
CUL1:FBXW11:SKP1 [cytosol]
(Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol]
(Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol]
(Gallus gallus)
CUL1:FBXW11:SKP1 [cytosol]
(Mus musculus)
CUL1:FBXW11:SKP1 [cytosol]
(Saccharomyces cerevisiae)
CUL1:FBXW11:SKP1 [cytosol]
(Schizosaccharomyces pombe)
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