TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
Deng, L, Inoue, J, Akkaraju, GR, Hong, M, Wang, C, Chen, ZJ
Shinohara, H, Sakurai, H, Sanjo, H, Aiba, Y, Hamadate, M, Yasuda, T, Watarai, H, Kurosaki, T
Zeng, XF, Wu, XL, Lipsky, PE, Zhang, W, Crammer, AC, He, LS, Zhang, X
Shinohara, H, Kurosaki, T
Dixit, VM, O'Rourke, K, Eby, M, Ultsch, M, Xiao, W, Wertz, I, Zhou, H, Seshagiri, S
protein serine/threonine kinase activity of p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane]
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