Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SOCS2 [cytosol]
Stable Identifier
R-HSA-1169204
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Suppressor of cytokine signaling 2, SOCS2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q15369 ELOC
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to SOCS2 (Homo sapiens)
SOCS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14508 SOCS2
Gene Names
SOCS2, CIS2, SSI2, STATI2
Chain
chain:1-198
Reference Genes
BioGPS Gene:8835 SOCS2
COSMIC (genes):SOCS2 SOCS2
CTD Gene:8835 SOCS2
dbSNP Gene:8835 SOCS2
ENSEMBL:ENSG00000120833 SOCS2
ENSEMBL_homo_sapiens_GENE:ENSG00000120833.14 SOCS2
HGNC:19382 SOCS2
KEGG Gene (Homo sapiens):8835 SOCS2
Monarch:8835 SOCS2
NCBI Gene:8835 SOCS2
OMIM:605117 SOCS2
UCSC:O14508 SOCS2
Reference Transcript
RefSeq:NM_001270471.1 SOCS2
RefSeq:NM_001270469.1 SOCS2
RefSeq:NM_003877.4 SOCS2
RefSeq:NM_001270467.1 SOCS2
RefSeq:NM_001270470.1 SOCS2
RefSeq:XM_017020156.1 SOCS2
RefSeq:NM_001270468.1 SOCS2
Other Identifiers
11735148_a_at
11751612_a_at
16755131
203372_PM_s_at
203372_s_at
203373_PM_at
203373_at
3426261
3426262
3426263
3426264
3426265
3426266
3426267
3426268
3426270
3426271
3426272
3426273
3426274
3426277
3426278
3426279
3426280
3426281
3426282
3426283
3426284
3426285
3426286
38994_at
44795_at
7957551
8835
A_14_P121737
A_23_P128215
A_24_P230675
GE58315
GO:0001558
GO:0005131
GO:0005159
GO:0005515
GO:0005737
GO:0005829
GO:0005942
GO:0006629
GO:0007259
GO:0007595
GO:0008269
GO:0009966
GO:0009968
GO:0012501
GO:0016567
GO:0023052
GO:0030154
GO:0032355
GO:0032870
GO:0035556
GO:0036211
GO:0040014
GO:0040015
GO:0043066
GO:0045666
GO:0046426
GO:0046854
GO:0046935
GO:0048856
GO:0060090
GO:0060396
GO:0060749
GO:0098772
HMNXSV003009470
HMNXSV003049848
ILMN_1798926
ILMN_2131861
PH_hs_0019226
TC12000726.hg
g2443360_3p_a_at
g4507262_3p_at
Participates
as a member of
CISH,SOCS1,SOCS2 [cytosol] (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
as a candidate of
SOCS [cytosol] (Homo sapiens)
FLT3 ubiquitin ligases [cytosol] (Homo sapiens)
as an input of
Active FLT3 binds to SOCS2 (Homo sapiens)
as a component of
active FLT3:SOCS2 [plasma membrane] (Homo sapiens)
Inferred To
SOCS2 [cytosol]
(Bos taurus)
SOCS2 [cytosol]
(Canis familiaris)
SOCS2 [cytosol]
(Gallus gallus)
SOCS2 [cytosol]
(Sus scrofa)
Socs2 [cytosol]
(Mus musculus)
Socs2 [cytosol]
(Rattus norvegicus)
socs2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001257398.1
,
NP_001257400.1
,
NP_001257396.1
,
NP_003868.1
,
XP_016875645.1
,
NP_001257397.1
,
NP_001257399.1
OpenTargets
ENSG00000120833
GeneCards
O14508
HPA
ENSG00000120833-SOCS2
Ensembl
ENSP00000447161
,
ENST00000549206
,
ENSP00000449227
,
ENST00000340600
,
ENST00000549122
,
ENSP00000339428
,
ENSP00000448815
,
ENSG00000120833
,
ENST00000551556
,
ENSP00000442898
,
ENSP00000481249
,
ENST00000622746
,
ENST00000536696
PRO
O14508
Pharos - Targets
O14508
PDB
2C9W
,
6I5J
,
7M6T
,
7ZLP
,
7ZLO
,
6I4X
,
7ZLS
,
7ZLM
,
4JGH
,
6I5N
,
7ZLR
,
7ZLN
,
5BO4
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.88
11
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.573
2
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:P40337-2 VHL
0.556
3
UniProt:Q15369-1 ELOC
0.544
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text