Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CISH [cytosol]
Stable Identifier
R-HSA-1169213
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cytokine-inducible SH2-containing protein, CIS, CISH_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
SOCS binding to GHR (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:CIS/SOCS1-3 [plasma membrane] (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
SOCS binding to JAK2 (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SOCS [plasma membrane] (Homo sapiens)
SOCS [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
SOCS [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
Expression of STAT5 upregulated genes (Homo sapiens)
CISH,SOCS1,SOCS2 [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
CISH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NSE2 CISH
Gene Names
CISH, G18
Chain
chain:1-258
Reference Genes
BioGPS Gene:1154 CISH
COSMIC (genes):CISH CISH
CTD Gene:1154 CISH
dbSNP Gene:1154 CISH
ENSEMBL:ENSG00000114737 CISH
ENSEMBL_homo_sapiens_GENE:ENSG00000114737.16 CISH
HGNC:1984 CISH
KEGG Gene (Homo sapiens):1154 CISH
Monarch:1154 CISH
NCBI Gene:1154 CISH
OMIM:602441 CISH
UCSC:Q9NSE2 CISH
Reference Transcript
RefSeq:NM_145071.2 CISH
RefSeq:XM_011533329.2 CISH
RefSeq:NM_013324.5 CISH
Other Identifiers
1154
11724843_s_at
16954567
221223_PM_x_at
221223_x_at
223377_PM_x_at
223377_x_at
223961_PM_s_at
223961_s_at
2675503
2675505
2675506
2675507
2675508
2675509
2675510
2675511
2675515
2675517
2675518
55059_at
8087739
A_23_P144096
A_24_P97465
GE54892
GO:0001558
GO:0003674
GO:0005515
GO:0005575
GO:0005829
GO:0005886
GO:0005942
GO:0006629
GO:0007205
GO:0009968
GO:0016567
GO:0023052
GO:0035556
GO:0036211
GO:0046854
GO:0046935
GO:0098772
HMNXSV003007619
HMNXSV003049296
ILMN_1738207
PH_hs_0000882
TC03001435.hg
g7209806_3p_a_at
Participates
as a member of
CISH,SOCS1,SOCS2 [cytosol] (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
as a candidate of
SOCS [cytosol] (Homo sapiens)
Inferred To
cish [cytosol]
(Xenopus tropicalis)
cishb [cytosol]
(Danio rerio)
CISH [cytosol]
(Bos taurus)
CISH [cytosol]
(Canis familiaris)
CISH [cytosol]
(Gallus gallus)
CISH [cytosol]
(Sus scrofa)
Cish [cytosol]
(Mus musculus)
Cish [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_659508.1
,
XP_011531631.1
,
NP_037456.5
OpenTargets
ENSG00000114737
GeneCards
Q9NSE2
HPA
ENSG00000114737-CISH
Ensembl
ENSG00000114737
,
ENST00000348721
,
ENSP00000409346
,
ENSP00000294173
,
ENST00000443053
PRO
Q9NSE2
Pharos - Targets
Q9NSE2
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.737
4
UniProt:O14773 TPP1
1
TPP1 [lysosomal lumen]
(R-HSA-535504)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text