ISGylation of IRF3

Stable Identifier
R-HSA-1169394
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ISGylation of IRF3
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The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.

Literature References
PubMed ID Title Journal Year
16914094 ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation

Knobeloch, KP, Okumura, A, Pitha-Rowe, I, Lu, G, Reinert, JT, Pitha-Rowe, PM, Kellum, M, Hassel, B

Cell Mol Biol (Noisy-le-grand) 2006
20308324 Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

Liu, X, Shi, HX, Yang, K, Zhu, LH, Wei, B, Wang, C, Shan, YF, Liu, XY

Mol Cell Biol 2010
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
ISGylation of IRF3 (Bos taurus)
ISGylation of IRF3 (Mus musculus)
ISGylation of IRF3 (Rattus norvegicus)
ISGylation of IRF3 (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
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