ISGylation of viral protein NS1

Stable Identifier
R-HSA-1169395
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ISGylation of viral protein NS1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Some viral proteins are also targeted for ISGylation. The well studied viral protein ISGylation is the modification of the influenza A viral protein NS1, which functions as an IFN antagonist during viral infection. Studies identified seven lysine residues in NS1 as potential ISGylation sites among which K41 (Zhao et al. 2010), K126 and K217 (Tang et al. 2010) were found to be critical. ISGylation at these sites disrupts NS1 association with importin-alpha, a protein required for the nuclear import of NS1.

Literature References
PubMed ID Title Journal Year
20219937 Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein

Garcia-Sastre, A, Wolff, T, van Boheemen, S, Hale, BG, Versteeg, GA, Lenschow, DJ

J Virol 2010
20133869 ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

Krug, RM, Kuo, RL, Zhao, C, Hsiang, TY

Proc Natl Acad Sci U S A 2010
20385878 Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein

Shan, Y, Liu, X, Zhu, L, Tang, Y, Bu, Z, Wang, C, Feng, H, Chen, H, Zhong, G

J Immunol 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
Cite Us!