Activation of ISG15 by UBA7 E1 enzyme

Stable Identifier
R-HSA-1169397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of ISG15 by UBA7 E1 enzyme
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Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction.
Literature References
PubMed ID Title Journal Year
19073728 ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus

Giannakopoulos, NV, Arutyunova, E, Lai, C, Lenschow, DJ, Haas, AL, Virgin, HW

J Virol 2009
18583345 The basis for selective E1-E2 interactions in the ISG15 conjugation system

Durfee, LA, Kelley, ML, Huibregtse, JM

J Biol Chem 2008
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Catalyst Activity

ISG15 activating enzyme activity of UBA7 [cytosol]

Physical Entity
UBA7 [cytosol] (Homo sapiens)
Activity
ISG15 activating enzyme activity (GO:0019782)
Orthologous Events
Activation of ISG15 by UBA7 E1 enzyme (Bos taurus)
Activation of ISG15 by UBA7 E1 enzyme (Caenorhabditis elegans)
Activation of ISG15 by UBA7 E1 enzyme (Canis familiaris)
Activation of ISG15 by UBA7 E1 enzyme (Dictyostelium discoideum)
Activation of ISG15 by UBA7 E1 enzyme (Mus musculus)
Activation of ISG15 by UBA7 E1 enzyme (Rattus norvegicus)
Activation of ISG15 by UBA7 E1 enzyme (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
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