Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction.
Virgin, HW, Haas, AL, Lai, C, Lenschow, DJ, Arutyunova, E, Giannakopoulos, NV
Durfee, LA, Huibregtse, JM, Kelley, ML
ubiquitin-protein transferase activity of UBA7 [cytosol]
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