Activation of ISG15 by UBA7 E1 ligase

Stable Identifier
R-HSA-1169397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of ISG15 by UBA7 E1 ligase
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Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction.

Literature References
PubMed ID Title Journal Year
19073728 ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus

Virgin, HW, Haas, AL, Lai, C, Lenschow, DJ, Arutyunova, E, Giannakopoulos, NV

J Virol 2009
18583345 The basis for selective E1-E2 interactions in the ISG15 conjugation system

Durfee, LA, Huibregtse, JM, Kelley, ML

J Biol Chem 2008
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Output
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Catalyst Activity

ubiquitin-protein transferase activity of UBA7 [cytosol]

Physical Entity
UBA7 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Activation of ISG15 by UBA7 E1 ligase (Bos taurus)
Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)
Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)
Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)
Activation of ISG15 by UBA7 E1 ligase (Mus musculus)
Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)
Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
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