Reactome | ISGylation of E2 conjugating enzymes

ISGylation of E2 conjugating enzymes

Stable Identifier

R-HSA-1169402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16112642	ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity Yokosawa, H, Takeuchi, T	Biochem Biophys Res Commun	2005
16428300	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme Yokosawa, H, Sasajima, H, Iwahara, S, Saeki, Y, Takeuchi, T	J Biochem	2005
16122702	ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin Zhang, DE, Dao, C, Malakhova, O, Papov, V, Kim, KI, Li, J, Zou, W	Biochem Biophys Res Commun	2005