Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005).
Yokosawa, H, Takeuchi, T
Yokosawa, H, Sasajima, H, Iwahara, S, Saeki, Y, Takeuchi, T
Zhang, DE, Dao, C, Malakhova, O, Papov, V, Kim, KI, Li, J, Zou, W
ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
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