ISGylation of protein phosphatase 1 beta (PP2CB)

Stable Identifier
R-HSA-1169405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ISGylation of protein phosphatase 1 beta (PP2CB)
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Protein phosphatase 1 beta (PPM1B/PP2CB) is a target for ISG15. PP2CB dephosphorylates TAK1 and suppresses TAK1/TAB1-mediated IkB alpha degradation and thereby controls the NF-kB signaling pathway, which plays a critical role in innate and adaptive immunity and cancer. ISGylation of PP2CB may block the suppressive function of the phosphatase against TAK1/TAB1 mediated NF-kB activation.

Literature References
PubMed ID Title Journal Year
16872604 Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation

Yokosawa, H, Tamura, S, Kobayashi, T, Takeuchi, T

FEBS Lett 2006
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Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)
ISGylation of protein phosphatase 1 beta (PP2CB) (Canis familiaris)
ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
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