Reactome | ISGylation of host proteins

ISGylation of host proteins

Stable Identifier

R-HSA-1169406

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Many host proteins are targets for ISGylation including constitutively expressed proteins involved in various cellular pathways such as immunity, RNA splicing, chromatin remodeling/polymerase II transcription, stress responses and translation. Many ISG15 target proteins are IFN alpha/beta-induced antiviral proteins such as PKR, MxA, IRF3, and RIG-I, also included are several key regulators of signal transduction such as PLC gamma1, JAK1, STAT1 and ERK1. The contribution of most of these modified proteins to antiviral activity is unclear because the fate of the vast majority of ISGylated target proteins is unknown.

Literature References

PubMed ID	Title	Journal	Year
16139798	Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Virgin, HW, Zhang, DE, Jacobs, BS, Luo, JK, Borden, EC, Papov, V, Li, J, Zou, W, Lenschow, DJ, Giannakopoulos, NV	Biochem Biophys Res Commun	2005
16009940	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways Denison, C, Krug, RM, Huibregtse, JM, Gygi, S, Zhao, C	Proc Natl Acad Sci U S A	2005
12582176	High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction Malakhova, OA, Malakhov, MP, Zhang, DE, Jacobs, BS, Borden, EC, Kim, KI	J Biol Chem	2003