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SHC1-2,SHC1-3 [cytosol]
Stable Identifier
R-HSA-1169480
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC1 p46,p52, SHC1 p46 and p52
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK mutants bind SHC (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
ALK mutants phosphorylate SHC1 (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Active ALK phosphorylates SHC1 (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
SHC-mediated cascade:FGFR1 (Homo sapiens)
Activated FGFR1 binds SHC1 (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Activated FGFR1 phosphorylates SHC1 (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
SHC-mediated cascade:FGFR2 (Homo sapiens)
Activated FGFR2 binds SHC1 (Homo sapiens)
Activated FGFR2:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Activated FGFR2 phosphorylates SHC1 (Homo sapiens)
Activated FGFR2:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
SHC-mediated cascade:FGFR3 (Homo sapiens)
Activated FGFR3 binds SHC1 (Homo sapiens)
Activated FGFR3:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Activated FGFR3 phosphorylates SHC1 (Homo sapiens)
Activated FGFR3:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through RAS (Homo sapiens)
NTRK2 phosphorylates SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through RAS (Homo sapiens)
Activated NTRK3 binds SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
NTRK3 phosphorylates SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
General
SHC1 isoforms p46 and p52 are found in B cells (Smit et al. 1994).
Literature References
PubMed ID
Title
Journal
Year
8051109
B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins
Bos, JL
,
Smit, L
,
de Vries-Smits, AM
,
Borst, J
J Biol Chem
1994
Participants
members
SHC1-3 [cytosol]
(Homo sapiens)
SHC1-2 [cytosol]
(Homo sapiens)
Participates
as a component of
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR3:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
as an input of
ALK mutants bind SHC (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
Activated NTRK3 binds SHC1 (Homo sapiens)
Activated FGFR3 binds SHC1 (Homo sapiens)
Activated FGFR1 binds SHC1 (Homo sapiens)
Activated FGFR2 binds SHC1 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Inferred To
Shc [cytosol]
(Drosophila melanogaster)
Shc1 [cytosol]
(Mus musculus)
Shc1 [cytosol]
(Rattus norvegicus)
Ghost homologue of SHC1-2,SHC1-3 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of SHC1-2,SHC1-3 [cytosol]
(Danio rerio)
Ghost homologue of SHC1-2,SHC1-3 [cytosol]
(Xenopus tropicalis)
SHC1 [cytosol]
(Bos taurus)
SHC1 [cytosol]
(Canis familiaris)
SHC1 [cytosol]
(Gallus gallus)
SHC1 [cytosol]
(Sus scrofa)
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