Reactome | KPNA3 [cytosol]

KPNA3 [cytosol]

Stable Identifier

R-HSA-1176070

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Importin subunit alpha-3, IMA3, IMA3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00505 KPNA3

Gene Names

KPNA3, QIP2

Chain

initiator methionine:1, chain:2-521

Reference Genes

BioGPS Gene:3839 KPNA3

COSMIC (genes):KPNA3 KPNA3

CTD Gene:3839 KPNA3

dbSNP Gene:3839 KPNA3

ENSEMBL:ENSG00000102753 KPNA3

HGNC:6396 KPNA3

KEGG:hsa:3839 KPNA3

Monarch:3839 KPNA3

NCBI Gene:3839 KPNA3

OMIM:601892 KPNA3

UCSC:O00505 KPNA3

Reference Transcript

RefSeq:NM_002267.3 KPNA3

Other Identifiers

11718199_at

11718200_at

16779119

221502_PM_at

221502_at

221503_PM_s_at

221503_s_at

2432644

3366375

3513878

3513879

3513884

3513885

3513886

3513887

3513888

3513889

3513890

3513892

3513893

3513894

3513895

3513896

3513897

3513899

3513900

3513901

3513902

3513903

3513908

3513910

3513911

3513912

3513917

3513931

3513932

35725_at

3839

54145_at

7971620

A_23_P139950

A_33_P3214884

GE57439

GE86064

GO:0005515

GO:0005634

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0042564

GO:0043657

GO:0046718

GO:0061608

GO:0065003

GO:0075732

GO:0140104

HMNXSV003049364

Hs.3886.0.A2_3p_at

ILMN_1708427

PH_hs_0024706

TC13000663.hg

Y12394_at

g2654138_3p_a_at

Participates

as a member of

Importin alpha [cytosol] (Homo sapiens)

Other forms of this molecule

KPNA3 [nucleoplasm]

Cross References

RefSeq

NP_002258.2

ENSEMBL

ENSP00000261667, ENSG00000102753, ENST00000261667

OpenTargets

ENSG00000102753

GeneCards

KPNA3

HPA

ENSG00000102753-KPNA3

PRO

O00505

Pharos - Targets

O00505

GlyGen

O00505

HMDB Protein

HMDBP08458

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.845	7
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.742	5
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.688	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	11
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	9
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	8
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.638	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.59	2
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.576	4
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q8WWX8 SLC5A11	1	SLC5A11 [plasma membrane] (R-HSA-429589)	0.556	3
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.556	3
UniProt:P43351 RAD52	3	p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588) RAD52 [nucleoplasm] (R-HSA-62639) monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909)	0.556	3
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.527	3
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2

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