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ACVR1C [plasma membrane]
Stable Identifier
R-HSA-1181117
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Activin receptor type-1C, ACV1C_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Regulation of signaling by NODAL (Homo sapiens)
LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
LEFTY1,2:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
The NODAL Receptor binds NODAL ligands (Homo sapiens)
NODAL Ligand:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)
NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
ACVR1C [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NER5 ACVR1C
Gene Names
ACVR1C, ALK7
Chain
signal peptide:1-20, chain:21-493
Reference Genes
BioGPS Gene:130399 ACVR1C
COSMIC (genes):ACVR1C ACVR1C
CTD Gene:130399 ACVR1C
dbSNP Gene:130399 ACVR1C
ENSEMBL:ENSG00000123612 ACVR1C
ENSEMBL_homo_sapiens_GENE:ENSG00000123612.16 ACVR1C
HGNC:18123 ACVR1C
KEGG Gene (Homo sapiens):130399 ACVR1C
Monarch:130399 ACVR1C
NCBI Gene:130399 ACVR1C
OMIM:608981 ACVR1C
UCSC:Q8NER5 ACVR1C
Reference Transcript
RefSeq:NM_001111032.1 ACVR1C
RefSeq:NM_145259.2 ACVR1C
RefSeq:NM_001111031.1 ACVR1C
RefSeq:NM_001111033.1 ACVR1C
Other Identifiers
11733618_a_at
11733619_a_at
11742016_a_at
130399
1552519_PM_at
1552519_at
1563182_PM_at
1563182_at
16903953
2582499
2582501
2582503
2582505
2582507
2582511
2582513
2582515
2582517
2582521
2582523
2582525
2582527
2582533
2582535
2582539
2582551
2582553
8055992
A_23_P397455
A_32_P190944
A_33_P3327404
GE521219
GO:0000166
GO:0001834
GO:0002021
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005524
GO:0005886
GO:0006468
GO:0006915
GO:0007178
GO:0007399
GO:0009749
GO:0010604
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016361
GO:0016740
GO:0019838
GO:0019915
GO:0022414
GO:0023052
GO:0030073
GO:0030154
GO:0030262
GO:0032868
GO:0032924
GO:0036211
GO:0038092
GO:0038100
GO:0043065
GO:0043167
GO:0043280
GO:0046676
GO:0046872
GO:0048179
GO:0048856
GO:0048870
GO:0051173
GO:0051239
GO:0060089
GO:0071363
GO:0080090
GO:0098802
GO:0140096
GO:1901164
GO:1901383
HMNXSV003000854
HMNXSV003012270
Hs2.352338.1.S1_3p_at
Hs2.382657.1.S1_3p_at
ILMN_1689217
ILMN_1917316
PH_hs_0017062
TC02002453.hg
Participates
as a component of
ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
as an input of
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
Other forms of this molecule
p-T175,S177,S179,S181,T194-ACVR1C [plasma membrane]
Cross References
RefSeq
NP_001104501.1
,
NP_001104502.1
,
NP_660302.2
,
NP_001104503.1
Guide to Pharmacology - Targets
1790
OpenTargets
ENSG00000123612
IntEnz
2.7.11.30
HPA
ENSG00000123612-ACVR1C
GeneCards
Q8NER5
Ensembl
ENSP00000243349
,
ENST00000335450
,
ENSP00000335178
,
ENST00000348328
,
ENST00000243349
,
ENST00000409680
,
ENSP00000387168
,
ENSG00000123612
,
ENSP00000335139
PRO
Q8NER5
Pharos - Targets
Q8NER5
HMDB Protein
HMDBP08703
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