Reactome | ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

Stable Identifier

R-HSA-1181149

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

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Upon binding Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), or Activin B (INHBB:INHBB), the type II component of the activin receptor (ACVR2A or ACVR2B) phosphorylates the type I component ACVR1B (ALK4) at multiple serine and threonine residues within the GS domain (Attisano et al. 1996, Willis et al. 1996, Willis and Mathews 1997, Zhou et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
15123686	An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors Donaldson, C, Gray, PC, Vale, W, Choe, S, Fischer, WH, Harrison, CA	J Biol Chem	2004
9459292	Regulation of activin type I receptor function by phosphorylation of residues outside the GS domain Willis, SA, Mathews, LS	FEBS Lett	1997
11117535	Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling Zhang, X, Klibanski, A, Zhou, Y, Sigai, DP, Danila, DC, Sun, H, Johnson, SR	Mol Endocrinol	2000
8721982	Formation and activation by phosphorylation of activin receptor complexes Willis, SA, Mathews, LS, Zimmerman, CM, Li, LI	Mol Endocrinol	1996
8622651	Activation of signalling by the activin receptor complex Massague, J, Wrana, JL, Attisano, L, Montalvo, E	Mol Cell Biol	1996