Cleavage of NODAL proprotein

Stable Identifier
R-HSA-1181152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Either FURIN or PACE4 endoproteases cleave the 321 amino acid NODAL proprotein to yield the 110 amino acid NODAL mature protein. In cultured mouse cells the CRIPTO coreceptor at the plasma membrane recruits both NODAL proprotein and FURIN or PACE4 endoprotease.

Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of FURIN, PACE4 [extracellular region]

Inferred From
Authored
Reviewed
Created
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