Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Stable Identifier
Reaction [binding]
Homo sapiens
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Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1B (ALK4) (Attisano et al. 1996, Zhou et al. 2000). Activin appears to interact initially with the type II receptor component (Attisano et al. 1996). It is unclear if the type II and type I receptors are associated before binding Activin. Any of Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), and Activin B (INHBB:INHBB) can bind and signal via an activin receptor containing the ACVR1B (ALK4) type I receptor. Also, TGFBR3 (Betaglycan) antagonises Activin signalling by binding with Inhibin A and ACVR2A (ActRII). TGFBR3 and Activin compete for ACVR2A and TGFBR3 thus inhibits activin signalling (Lewis et al. 2000, Waiter et al. 2003).
Literature References
PubMed ID Title Journal Year
8196624 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

Massague, J, Wrana, JL, Weis, FM, Carcamo, J, Wieser, R, Attisano, L, Ventura, F

Mol Cell Biol 1994
11117535 Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

Zhang, X, Klibanski, A, Zhou, Y, Sigai, DP, Danila, DC, Sun, H, Johnson, SR

Mol Endocrinol 2000
9032295 Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

Lebrun, JJ, Vale, WW

Mol Cell Biol 1997
8622651 Activation of signalling by the activin receptor complex

Massague, J, Wrana, JL, Attisano, L, Montalvo, E

Mol Cell Biol 1996
This event is regulated
Orthologous Events
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