Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL

Stable Identifier
R-HSA-1181156
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL
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As inferred from the response of the activin receptor to activin, the type II component of the NODAL receptor phosphorylates the type I component in response to NODAL binding. Experiments with human proteins in frog oocytes show NODAL can signal via the CRIPTO:ACVR1B(ALK4):ACVR2 complex (Yeo and Whitman 2001).

Literature References
PubMed ID Title Journal Year
11389842 Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms

Yeo, C, Whitman, M

Mol Cell 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane]

Physical Entity
NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
Authored
May, B  (2011-01-23)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-01-28)
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