EGFR E746_A750del [plasma membrane]

Stable Identifier
R-HSA-1181211
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Epidermal Growth Factor Receptor E746_A750del, EGFR Glu746_Ala750del
Icon
EGFR E746_A750del [plasma membrane] icon
EGFR E746_A750del [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
15118073 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Bell, DW, Lynch, TJ, Harris, PL, Brannigan, BW, Supko, JG, Gurubhagavatula, S, Louis, DN, Christiani, DC, Okimoto, RA, Haber, DA, Haluska, FG, Haserlat, SM, Settleman, J, Sordella, R

N Engl J Med 2004
External Reference Information
External Reference
UniProt:P00533 EGFR
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Reference Genes
BioGPS Gene:1956 EGFR
COSMIC (genes):EGFR EGFR
CTD Gene:1956 EGFR
dbSNP Gene:1956 EGFR
ENSEMBL:ENSG00000146648 EGFR
ENSEMBL_homo_sapiens_GENE:ENSG00000146648.21 EGFR
HGNC:3236 EGFR
KEGG Gene (Homo sapiens):1956 EGFR
Monarch:1956 EGFR
NCBI Gene:1956 EGFR
OMIM:131550 EGFR
UCSC:P00533 EGFR
Reference Transcript
Other Identifiers
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1537_at
1565483_PM_at
1565483_at
1565484_PM_x_at
1565484_x_at
17046135
1956
201983_PM_s_at
201983_s_at
201984_PM_s_at
201984_s_at
210984_PM_x_at
210984_x_at
211550_PM_at
211550_at
211607_PM_x_at
211607_x_at
224999_PM_at
224999_at
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
3002821
3002822
3002823
3002824
3002825
37327_at
48285_at
65700_at
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
GE59632
GO:0000139
GO:0000165
GO:0000166
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001889
GO:0001892
GO:0001934
GO:0001942
GO:0003013
GO:0003677
GO:0003682
GO:0003690
GO:0003824
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005102
GO:0005178
GO:0005515
GO:0005516
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006412
GO:0006468
GO:0006629
GO:0006954
GO:0006979
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007202
GO:0007435
GO:0007494
GO:0007611
GO:0007623
GO:0008092
GO:0008283
GO:0008284
GO:0008544
GO:0009925
GO:0009986
GO:0010008
GO:0012501
GO:0014070
GO:0016020
GO:0016101
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021795
GO:0022008
GO:0022414
GO:0023052
GO:0030054
GO:0030139
GO:0030154
GO:0030163
GO:0030296
GO:0030297
GO:0030307
GO:0030324
GO:0030335
GO:0030669
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032355
GO:0032587
GO:0032930
GO:0032991
GO:0033138
GO:0033590
GO:0033594
GO:0033993
GO:0034614
GO:0035556
GO:0036211
GO:0038083
GO:0038127
GO:0038134
GO:0042059
GO:0042127
GO:0042177
GO:0042311
GO:0042327
GO:0042698
GO:0042743
GO:0042802
GO:0043066
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043586
GO:0044877
GO:0045121
GO:0045296
GO:0045737
GO:0045739
GO:0045740
GO:0045780
GO:0045893
GO:0045907
GO:0045930
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0048143
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048661
GO:0048812
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050730
GO:0050877
GO:0051015
GO:0051117
GO:0051205
GO:0051592
GO:0051896
GO:0051897
GO:0051968
GO:0060089
GO:0060252
GO:0060571
GO:0061024
GO:0061029
GO:0070141
GO:0070257
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071260
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0071466
GO:0071549
GO:0072659
GO:0090263
GO:0097421
GO:0097489
GO:0097708
GO:0098590
GO:0098609
GO:0098772
GO:0140096
GO:1900020
GO:1900087
GO:1901224
GO:1902722
GO:1902895
GO:1903078
GO:1905208
HMNXSV003006702
HMNXSV003057307
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1696521
ILMN_1728858
ILMN_1755535
ILMN_1798975
PH_hs_0004462
PH_hs_0014421
TC07000328.hg
TC07002321.hg
TC07002322.hg
X00588_at
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
p26428
Participates
as a member of
Other forms of this molecule
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
p-5Y-EGFRvIII [plasma membrane]
EGFRvIII [plasma membrane]
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
p-6Y-EGFR L858R;T790M [plasma membrane]
p-6Y-EGFR A767_V769dup [plasma membrane]
p-6Y-EGFR N771_H773dup [plasma membrane]
p-6Y-EGFR K739_I744dup [plasma membrane]
p-6Y-EGFR D770_N771insNPG [plasma membrane]
p-6Y-EGFR E746_A750del [plasma membrane]
p-6Y-EGFR L858R [plasma membrane]
p-6Y-EGFR G719S [plasma membrane]
p-6Y-EGFR L747_P753delinsS [plasma membrane]
p-6Y-EGFR L747_A750delinsP [plasma membrane]
p-6Y-EGFR L747_T751del [plasma membrane]
p-6Y-EGFR L747_S752del [plasma membrane]
p-6Y-EGFR L747_T751delinsP [plasma membrane]
p-6Y-EGFR E746_T751delinsA [plasma membrane]
p-6Y-EGFR E746_S752delinsV [plasma membrane]
p-6Y-EGFR L861Q [plasma membrane]
p-6Y-EGFR A289V [plasma membrane]
p-6Y-EGFR T263P [plasma membrane]
p-6Y-EGFR G598V [plasma membrane]
p-6Y-EGFR R108K [plasma membrane]
p-6Y-EGFR A289T [plasma membrane]
p-6Y-EGFR G719C [plasma membrane]
p-6Y-EGFR A289D [plasma membrane]
p-6Y-EGFR G719A [plasma membrane]
EGFR L858R;T790M [plasma membrane]
EGFR E746_A750del;T790M [plasma membrane]
EGFR D770_N771insNPG [plasma membrane]
EGFR K739_I744dup [plasma membrane]
EGFR A767_V769dup [plasma membrane]
EGFR N771_H773dup [plasma membrane]
EGFR L858R [plasma membrane]
EGFR G719S [plasma membrane]
EGFR L747_P753delinsS [plasma membrane]
EGFR A289V [plasma membrane]
EGFR L747_T751delinsP [plasma membrane]
EGFR L747_T751del [plasma membrane]
EGFR A289D [plasma membrane]
EGFR L861Q [plasma membrane]
EGFR R108K [plasma membrane]
EGFR L747_A750delinsP [plasma membrane]
EGFR E746_T751delinsA [plasma membrane]
EGFR G719A [plasma membrane]
EGFR A289T [plasma membrane]
EGFR E746_S752delinsV [plasma membrane]
EGFR G719C [plasma membrane]
EGFR T263P [plasma membrane]
EGFR G598V [plasma membrane]
EGFR L747_S752del [plasma membrane]
EGFR [endosome membrane]
p-4Y-EGFR [plasma membrane]
p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
EGFR [plasma membrane]
p-Y1086,Y1101-EGFR [plasma membrane]
p-6Y-EGFR [plasma membrane]
Modified Residues
Name
Deletion of residues 746 to 750
Disease
Name Identifier Synonyms
parotid gland cancer DOID:9036 malignant tumor of parotid gland (disorder), malignant neoplasm of the Parotid, cancer of parotid gland
lung cancer DOID:1324
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
thyroid cancer DOID:1781 Thyroid gland neoplasm, thyroid cancer, thyroid neoplasm, neoplasm of thyroid gland, thyroid neoplasm, Thyroid neoplasm, malignant tumour of thyroid gland, malignant neoplasm of thyroid gland
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
kidney cancer DOID:263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
renal clear cell carcinoma DOID:4467 conventional renal cell carcinoma, Clear cell carcinoma of kidney (disorder), conventional (Clear cell) renal cell carcinoma
papillary thyroid carcinoma DOID:3969 Papillary carcinoma of the Thyroid gland, Papillary carcinoma of thyroid, Papillary thyroid carcinoma (disorder)
salivary gland cancer DOID:8850 malignant neoplasm of salivary gland NOS, malignant tumor of the Salivary gland, malignant neoplasm of salivary gland duct, malignant neoplasm of major salivary gland, NOS, malignant neoplasm of major salivary gland NOS (disorder), malignant neoplasm of major salivary gland NOS, malignant neoplasm of salivary gland, malignant neoplasm of salivary gland, unspecified, malignant tumor of salivary gland (disorder), malignant tumor of major salivary gland (disorder), malignant tumor of the Major Salivary gland, malignant neoplasm of major salivary gland, malignant neoplasm of other major salivary glands (disorder), malignant neoplasm of other major salivary glands
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
6TG0, 8HV5, 4KRL, 2M0B, 4G5J, 4TKS, 5UGC, 2RGP, 4KRO, 2N5S, 6Z4B, 3VRP, 7LGS, 8A2A, 5ZTO, 3VRR, 4JR3, 7JXK, 5CZH, 1IVO, 5CZI, 8GB4, 8HGO, 7SZ7, 7VRE, 7LG8, 2ITP, 8TJL, 4JQ7, 6JX0, 8A27, 5JEB, 8DSW, 4RJ7, 8F1W, 7UKW, 6B3S, 8HV6, 4RJ8, 3LZB, 3W2P, 5CAL, 2ITX, 5Y25, 5J9Y, 5WB8, 5GNK, 2ITW, 6V6O, 5CAN, 8HGS, 3P0Y, 8A2B, 4WD5, 3NJP, 6S9D, 6TFZ, 7JXL, 6ARU, 8HGP, 1M14, 4RIW, 7A6I, 6JXT, 5GTZ, 6S8A, 4RIY, 5GMP, 4RJ5, 7ZYM, 5WB7, 2ITO, 2RFE, 2ITZ, 8F1X, 6TFY, 4JQ8, 7LFR, 4ZJV, 2JIU, 4KRM, 7OXB, 5HIB, 4KRP, 7SI1, 2RF9, 5C8K, 5CNN, 7U99, 5XGM, 6S89, 8H7X, 8HV4, 4LI5, 5XDK, 5C8M, 5UG9, 5CNO, 4I21, 5HG8, 4I1Z, 5EM6, 4R3P, 5X2F, 7B85, 5C8N, 4ZAU, 3OB2, 4I23, 7ZYQ, 5EM7, 6JRJ, 6TFU, 2JIV, 8EME, 5ZWJ, 7SZ1, 6P1D, 7LEN, 2RFD, 7U9A, 6S9B, 6TFW, 3OP0, 5UGB, 8WD4, 7UKV, 6JZ0, 7LFS, 7JXI, 6V66, 2ITV, 3QWQ, 5HIC, 6JRX, 5FED, 4HJO, 6V5P, 5EM5, 7OM4, 2EB3, 4LRM, 2KS1, 5GTY, 2EB2, 1YY9, 6JX4, 6LUB, 5UGA, 5X2K, 1Z9I, 7VRA, 5XDL, 7SZ5, 5HG9, 5Y9T, 7SYE, 2JIT, 5CAU, 6V5N, 4UV7, 4UIP, 8HY7, 7AEI, 8D73, 6JRK, 6P1L, 6TFV, 5CAV, 3VJN, 5HG5, 3GT8, 3W2S, 5YU9, 3GOP, 4I20, 7K1I, 6VHN, 2J6M, 2ITU, 5X27, 5FEE, 4I22, 5HCY, 5XGN, 1NQL, 6P8Q, 8HV1, 3BEL, 4R3R, 4I24, 3BUO, 7JXQ, 5EM8, 7ZYN, 7T4I, 6WAK, 8HV9, 2ITN, 5XWD, 3PFV, 5X2C, 4JRV, 6LUD, 2J5F, 3UG1, 7SZ0, 5X2A, 8HV3, 5UG8, 8F1H, 7U98, 3W33, 7TVD, 8HVA, 6JWL, 7ZYP, 7T4J, 8G63, 8HV2, 5HG7, 6VHP, 4R5S, 3B2V, 7AEM, 5X28, 3G5Y, 7ER2, 2GS7, 8D76, 5HCZ, 7JXW, 2GS6, 3C09, 4LL0, 6S9C, 6VH4, 8FV3, 5SX4, 5LV6, 6D8E, 7JXM, 4G5P, 3W2R, 2J5E, 7A6K, 5EDP, 3VJO, 6WA2, 1MOX, 8A2D, 7SYD, 5CAO, 5EDQ, 5SX5, 8F1Y, 2ITT, 6XL4, 5CAP, 4WRG, 6WXN, 2ITQ, 7A6J, 5CAQ, 7KXZ, 5CAS, 8HV7, 6Z4D, 4LQM, 6V6K, 7A2A, 3B2U, 8FV4, 5UWD, 5J9Z, 2ITY, 3W2Q, 4ZSE, 2GS2, 7JXP, 5U8L, 3UG2, 5X26, 1XKK, 4WKQ, 3W32, 2M20, 3IKA, 6DUK, 6TG1, 3POZ, 5EDR, 7K1H, 8F1Z, 5HCX, 7KY0, 4RJ4, 1M17, 4RIX, 8HV8, 5FEQ, 7LTX, 4RJ6, 5D41, 3W2O, 3G5V
ZINC - Investigational
ZINC - Metabolites
COSMIC
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (324)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.983 59
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P21860 ERBB3      0.919 14
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P12931 SRC  6 0.9 9
 UniProt:Q9UJM3 ERRFI      0.9 15
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:P16885 PLCG2  8 0.793 6
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  8 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  3 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:P12830 CDH1  8 0.735 4
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P46108 CRK  1 0.692 4
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P00519 ABL1  6 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:Q8TF42 UBS3B      0.69 7
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:P41240 CSK  2 0.681 3
 UniProt:O75368 SH3L1      0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:P35221 CTNNA1  2 0.68 5
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:Q07889 SOS1  3 0.669 3
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:P14923 JUP  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:P42229 STAT5A  4 0.635 4
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:Q14457 BECN1  4 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q13438 OS9  1 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:P04792 HSBP1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:Q8IZW8 TNS4  1 0.59 2
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P07355 ANXA2  6 0.583 4
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:O14965 AURKA  6 0.581 4
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.569 3
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:Q15303 ERBB4      0.564 3
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P07947 YES1  2 0.564 3
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:Q13153 PAK1  5 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:Q99704 DOK1  2 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:O14543 SOCS3  1 0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:P55036 PSMD4  1 0.553 2
 UniProt:O14818 PSMA7  2 0.553 2
 UniProt:Q99759 MAP3K3  1 0.553 2
 UniProt:P31321 PRKAR1B  2 0.553 2
 UniProt:P19438 TNFRSF1A  2 0.553 2
 UniProt:P26641 EEF1G  3 0.553 2
 UniProt:P49407 ARRB1  6 0.553 2
 UniProt:Q16186 ADRM1  2 0.553 2
 UniProt:P06132 UROD  1 0.553 2
 UniProt:P04075 ALDOA  6 0.553 2
 UniProt:O00401 WASL  4 0.553 2
 UniProt:Q13905 RAPGEF1  2 0.553 2
 UniProt:P41222 PTGDS  1 0.553 2
 UniProt:Q8TDI0 CHD5      0.553 2
 UniProt:P06396 GSN  7 0.553 2
 UniProt:Q8N2Y8 RUSC2      0.553 2
 UniProt:P42685 FRK  4 0.553 2
 UniProt:P10636 MAPT  3 0.553 2
 UniProt:Q13561 DCTN2  1 0.553 2
 UniProt:Q53GZ6 Q53GZ6      0.553 2
 UniProt:P17600 SYN1  2 0.553 2
 UniProt:P31939 ATIC  5 0.553 2
 UniProt:P54368 OAZ1  1 0.553 2
 UniProt:Q9UPY6 WASF3  3 0.553 2
 UniProt:P17174 GOT1  1 0.553 2
 UniProt:Q9NNZ3 DNJC4      0.553 2
 UniProt:Q9Y5X1 SNX9  3 0.553 2
 UniProt:Q14050 COL9A3  20 0.553 2
 UniProt:O94992 HEXI1      0.553 2
 UniProt:Q9Y3A3 PHOCN      0.553 2
 UniProt:Q96AD5 PNPLA2  4 0.553 2
 UniProt:O94875 SRBS2      0.553 2
 UniProt:P07949 RET  2 0.553 2
 UniProt:Q15819 UBE2V2  2 0.553 2
 UniProt:P45984 MAPK9  3 0.553 2
 UniProt:Q6UWJ1 TMCO3      0.553 2
 UniProt:Q99784 NOE1      0.553 2
 UniProt:Q92918 M4K1      0.553 2
 UniProt:Q07890 SOS2  1 0.553 2
 UniProt:P49798 RGS4  1 0.553 2
 UniProt:O75095 MEGF6      0.553 2
 UniProt:Q15120 PDK3  1 0.553 2
 UniProt:O43707 ACTN4  3 0.553 2
 UniProt:Q8N5H7 SH2D3      0.553 2
 UniProt:P11309 PIM1  1 0.553 2
 UniProt:Q02297 NRG1  1 0.553 2
 UniProt:P62330 ARF6  2 0.553 2
 UniProt:P52306 RAP1GDS1  1 0.553 2
 UniProt:Q15005 SPCS2  1 0.553 2
 UniProt:Q14155 ARHGEF7  1 0.553