Reactome | WHSC1 [nucleoplasm]

WHSC1 [nucleoplasm]

Stable Identifier

R-HSA-1183215

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable histone-lysine N-methyltransferase NSD2, NSD2_HUMAN, KMT3G, NSD2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O96028 NSD2

Gene Names

NSD2, KIAA1090, MMSET, TRX5, WHSC1

Chain

chain:1-1365

Reference Genes

COSMIC (genes):NSD2 NSD2

dbSNP Gene:7468 NSD2

ENSEMBL:ENSG00000109685 NSD2

Participates

as a member of

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)

as an input of

WHSC1 binds DNA DSBs (Homo sapiens)

Other forms of this molecule

p-S102-WHSC1 [nucleoplasm]

Inferred To

WHSC1 [nucleoplasm] (Dictyostelium discoideum)

WHSC1 [nucleoplasm] (Gallus gallus)

WHSC1 [nucleoplasm] (Mus musculus)

WHSC1 [nucleoplasm] (Plasmodium falciparum)

SET2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of WHSC1 [nucleoplasm] (Drosophila melanogaster)

NSD2 [nucleoplasm] (Bos taurus)

NSD2 [nucleoplasm] (Canis familiaris)

NSD2 [nucleoplasm] (Sus scrofa)

set2 [nucleoplasm] (Schizosaccharomyces pombe)

Nsd2 [nucleoplasm] (Rattus norvegicus)

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.615	3
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.602	5
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.591	3
UniProt:Q8N7B1 HORM2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P0DTD1-PRO_0000449626 REP			0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	2
UniProt:Q9NZM5 NOP53			0.527	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9BSG1 ZNF2	1	ZNF2 [nucleoplasm] (R-HSA-975031)	0.527	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:Q6ZN17 LN28B			0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2

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