Reactome | WHSC1 [nucleoplasm]

WHSC1 [nucleoplasm]

Stable Identifier

R-HSA-1183215

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable histone-lysine N-methyltransferase NSD2, NSD2_HUMAN, KMT3G, NSD2

Locations in the PathwayBrowser for interactor UniProt:O43159 RRP8

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External Reference Information

External Reference

UniProt:O96028 NSD2

Gene Names

NSD2, KIAA1090, MMSET, TRX5, WHSC1

Chain

chain:1-1365

Reference Genes

BioGPS Gene:7468 NSD2

COSMIC (genes):NSD2 NSD2

CTD Gene:7468 NSD2

dbSNP Gene:7468 NSD2

ENSEMBL:ENSG00000109685 NSD2

HGNC:12766 NSD2

KEGG:hsa:7468 NSD2

Monarch:7468 NSD2

NCBI Gene:7468 NSD2

OMIM:602952 NSD2

UCSC:O96028 NSD2

Reference Transcript

Participates

as a member of

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)

as an input of

WHSC1 binds DNA DSBs (Homo sapiens)

Other forms of this molecule

p-S102-WHSC1 [nucleoplasm]

Inferred To

WHSC1 [nucleoplasm] (Dictyostelium discoideum)

WHSC1 [nucleoplasm] (Gallus gallus)

WHSC1 [nucleoplasm] (Mus musculus)

WHSC1 [nucleoplasm] (Plasmodium falciparum)

SET2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of WHSC1 [nucleoplasm] (Drosophila melanogaster)

NSD2 [nucleoplasm] (Bos taurus)

NSD2 [nucleoplasm] (Canis familiaris)

NSD2 [nucleoplasm] (Sus scrofa)

set2 [nucleoplasm] (Schizosaccharomyces pombe)

Nsd2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016864076.1, XP_005248058.1, XP_016864077.1, NP_579890.1, XP_011511859.1, XP_006713977.1, NP_015627.1, XP_011511862.1, NP_001035889.1, NP_579878.1, XP_005248062.1, NP_579877.1, NP_579889.1

Guide to Pharmacology - Targets

3220

OpenTargets

ENSG00000109685

ENSEMBL

ENST00000312087, ENST00000382891, ENSG00000109685, ENST00000382892, ENST00000353275, ENST00000382895, ENSP00000423972, ENST00000398261, ENST00000678714, ENST00000420906, ENST00000382888, ENSP00000372344, ENSP00000504221, ENST00000503128, ENSP00000308780, ENSP00000425761, ENSP00000421681, ENSP00000372347, ENSP00000372348, ENST00000514045, ENSP00000399251, ENSP00000329167, ENST00000508803, ENSP00000381311, ENSP00000372351

GeneCards

NSD2

HPA

ENSG00000109685-NSD2

PRO

O96028

Pharos - Targets

O96028

GlyGen

O96028

Orphanet

NSD2

HMDB Protein

HMDBP09022

PDB

5VC8, 6XCG, 9EXX, 7E8D, 7CRO, 7LMT, 9EXY, 7VLN, 6UE6, 7MDN, 9EXW, 5LSU

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.615	3
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.602	5
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.591	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q8N7B1 HORM2			0.556	3
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:Q9BSG1 ZNF2	1	ZNF2 [nucleoplasm] (R-HSA-975031)	0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q9NZM5 NOP53			0.527	3
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P0DTD1-PRO_0000449626 REP			0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:Q6ZN17 LN28B			0.483	2

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