Reactome | KMT2A [nucleoplasm]

KMT2A [nucleoplasm]

Stable Identifier

R-HSA-1183223

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MLL1, Histone-lysine N-methyltransferase MLL, MLL, MLL1_HUMAN

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External Reference Information

External Reference

UniProt:Q03164 KMT2A

Gene Names

KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1

Chain

chain:1-3969, chain:1-2718, chain:2719-3969

Reference Genes

COSMIC (genes):KMT2A KMT2A

dbSNP Gene:4297 KMT2A

ENSEMBL:ENSG00000118058 KMT2A

Participates

as a component of

as an input of

KMT2A (MLL) binds RUNX1 (Homo sapiens)

Other forms of this molecule

KMT2A [cytosol]

KMT2A(2719-3969) [cytosol]

KMT2A(1-2718) [cytosol]

KMT2A(1-2718) [nucleoplasm]

KMT2A(2719-3969) [nucleoplasm]

Inferred To

KMT2A [nucleoplasm] (Bos taurus)

KMT2A [nucleoplasm] (Canis familiaris)

KMT2A [nucleoplasm] (Drosophila melanogaster)

KMT2A [nucleoplasm] (Gallus gallus)

KMT2A [nucleoplasm] (Mus musculus)

KMT2A [nucleoplasm] (Rattus norvegicus)

KMT2A [nucleoplasm] (Sus scrofa)

KMT2A [nucleoplasm] (Xenopus tropicalis)

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.956	14
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.937	11
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.883	9
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.729	5
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.725	5
IntAct:EBI-1801917 HOXA9			0.725	6
UniProt:Q9UNP9 PPIE	4	PPIE [nucleoplasm] (R-HSA-6781959) PPIE [secretory granule lumen] (R-HSA-6801369) PPIE [extracellular region] (R-HSA-6806493) PPIE [ficolin-1-rich granule lumen] (R-HSA-6801393)	0.704	4
UniProt:O00255-2 MEN1			0.702	12
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.675	11
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.667	4
UniProt:O00255 MEN1	4	MEN1 [cytosol] (R-HSA-5672315) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) MEN1 [nucleoplasm] (R-HSA-2186626)	0.643	3
UniProt:Q9UBL3-3 ASH2L			0.623	4
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.623	5
UniProt:Q9H7Z6 KAT8	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.591	3
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.576	5
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.576	4
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.558	7
UniProt:O75475 PSIP1	2	PSIP1 [cytosol] (R-HSA-3008840) PSIP1 [nucleoplasm] (R-HSA-3008841)	0.544	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.536	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.527	3
IntAct:EBI-1801907 HOXA7			0.527	4
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.527	2
UniProt:Q13309-1 SKP2			0.524	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.508	5
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.499	4
UniProt:Q9WTL8 Arntl	4	Arntl [nucleoplasm] (R-MMU-9769624) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [cytosol] (R-MMU-508660) p-S-Arntl [nucleoplasm] (R-MMU-508690)	0.499	3
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.499	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.483	2

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