Reactome | KMT2A [nucleoplasm]

KMT2A [nucleoplasm]

Stable Identifier

R-HSA-1183223

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MLL1, Histone-lysine N-methyltransferase MLL, MLL, MLL1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O00255 MEN1

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        KMT2A (MLL) binds RUNX1 (Homo sapiens)
        
        KMT2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03164 KMT2A

Gene Names

KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1

Chain

chain:1-3969, chain:1-2718, chain:2719-3969

Reference Genes

BioGPS Gene:4297 KMT2A

COSMIC (genes):KMT2A KMT2A

CTD Gene:4297 KMT2A

dbSNP Gene:4297 KMT2A

ENSEMBL:ENSG00000118058 KMT2A

HGNC:7132 KMT2A

KEGG:hsa:4297 KMT2A

Monarch:4297 KMT2A

NCBI Gene:4297 KMT2A

OMIM:159555 KMT2A

UCSC:Q03164 KMT2A

Reference Transcript

Participates

as a component of

as an input of

Other forms of this molecule

KMT2A(2719-3969) [nucleoplasm]

KMT2A(1-2718) [nucleoplasm]

KMT2A(1-2718) [cytosol]

KMT2A(2719-3969) [cytosol]

KMT2A [cytosol]

Inferred To

KMT2A [nucleoplasm] (Bos taurus)

KMT2A [nucleoplasm] (Canis familiaris)

KMT2A [nucleoplasm] (Drosophila melanogaster)

KMT2A [nucleoplasm] (Gallus gallus)

KMT2A [nucleoplasm] (Mus musculus)

KMT2A [nucleoplasm] (Rattus norvegicus)

KMT2A [nucleoplasm] (Sus scrofa)

KMT2A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005924.2, NP_001184033.1

Guide to Pharmacology - Targets

2688

ENSEMBL

ENSP00000436786, ENSP00000496927, ENST00000534358, ENSG00000118058, ENST00000649699, ENST00000389506, ENSP00000374157

OpenTargets

ENSG00000118058

ZINC - Substances

KMT2A_HUMAN

ZINC - Biogenic

KMT2A_HUMAN

ZINC target

Q03164

PRO

Q03164

GlyGen

Q03164

PDB

4GQ6, 6KIZ, 6U9K, 7S8A, 6U9N, 7MBM, 3LQJ, 7MBN, 6U9R, 5F5E, 7W6I, 6PWV, 5F6L, 3U88, 2MSR, 7W6A, 2AGH, 2JYI, 2W5Y, 7RZD, 2J2S, 7S79, 6KIU, 6KIV, 6W5N, 7S8F, 2LXS, 7ZEZ, 7S7D, 7U5V, 3EG6, 7W67, 3LQI, 3LQH, 6KIX, 6U9M, 6PWW, 7W6J, 4NW3, 3U85, 6EMQ, 2KU7, 5SVH, 2MTN, 3EMH, 2W5Z, 2KYU, 7RZJ, 6W5M, 6W5I, 2KKF, 3P4F, 7S8E, 2LXT, 7ZEY, 4ESG

ZINC - Metabolites

KMT2A_HUMAN

IntEnz

2.1.1.364

GeneCards

KMT2A

HPA

ENSG00000118058-KMT2A

Pharos - Targets

Q03164

Orphanet

KMT2A

ZINC - Predictions - Purchasable

KMT2A_HUMAN

HMDB Protein

HMDBP01970

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.959	17
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.937	11
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.883	9
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.729	5
IntAct:EBI-1801917 HOXA9			0.725	6
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.725	5
UniProt:Q9UNP9 PPIE	4	PPIE [nucleoplasm] (R-HSA-6781959) PPIE [ficolin-1-rich granule lumen] (R-HSA-6801393) PPIE [extracellular region] (R-HSA-6806493) PPIE [secretory granule lumen] (R-HSA-6801369)	0.704	4
UniProt:O00255-2 MEN1			0.702	12
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.675	11
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.667	4
UniProt:O00255 MEN1	4	MEN1 [nucleoplasm] (R-HSA-2186626) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [cytosol] (R-HSA-5672315)	0.643	3
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.623	5
UniProt:Q9UBL3-3 ASH2L			0.623	4
UniProt:Q9H7Z6 KAT8	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.591	3
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.576	4
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.576	5
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.558	7
UniProt:O75475 PSIP1	2	PSIP1 [cytosol] (R-HSA-3008840) PSIP1 [nucleoplasm] (R-HSA-3008841)	0.544	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.536	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.527	3
IntAct:EBI-1801907 HOXA7			0.527	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:Q13309-1 SKP2			0.524	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.508	5
UniProt:O08785 Clock	6	p-T451,T461-Clock [nucleoplasm] (R-MMU-9920668) Clock [cytosol] (R-MMU-508720) p-T451,T461-Clock [cytosol] (R-MMU-9920658) p-S-Clock [nucleoplasm] (R-MMU-508670) p-T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9920662) p-S,T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9927976)	0.499	3
UniProt:Q9WTL8 Arntl	7	p-S97-Bmal1 [nucleoplasm] (R-MMU-9920676) Arntl [cytosol] (R-MMU-508660) p-S97-Bmal1 [cytosol] (R-MMU-9912402) p-S-Arntl [nucleoplasm] (R-MMU-508690) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624) p-S97,Ac-544-Bmal1 [nucleoplasm] (R-MMU-9920664)	0.499	3
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.499	4
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.483	2

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