Reactome | EHMT1 [nucleoplasm]

EHMT1 [nucleoplasm]

Stable Identifier

R-HSA-1183226

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, EHMT1_HUMAN, KMT1D, G9a-like protein 1, GLP1, GLP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H9B1 EHMT1

Gene Names

EHMT1, EUHMTASE1, GLP, KIAA1876, KMT1D

Chain

initiator methionine:, chain:2-1298

Reference Genes

BioGPS Gene:79813 EHMT1

COSMIC (genes):EHMT1 EHMT1

CTD Gene:79813 EHMT1

dbSNP Gene:79813 EHMT1

ENSEMBL:ENSG00000181090 EHMT1

HGNC:24650 EHMT1

KEGG:hsa:79813 EHMT1

Monarch:79813 EHMT1

NCBI Gene:79813 EHMT1

OMIM:607001 EHMT1

UCSC:Q9H9B1 EHMT1

Reference Transcript

Participates

as a member of

EHMT1,2 [nucleoplasm] (Homo sapiens)

as a component of

Inferred To

EHMT1 [nucleoplasm] (Bos taurus)

EHMT1 [nucleoplasm] (Canis familiaris)

EHMT1 [nucleoplasm] (Gallus gallus)

EHMT1 [nucleoplasm] (Mus musculus)

EHMT1 [nucleoplasm] (Sus scrofa)

ehmt1 [nucleoplasm] (Xenopus tropicalis)

Ehmt1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of EHMT1 [nucleoplasm] (Dictyostelium discoideum)

G9a [nucleoplasm] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

2651

OpenTargets

ENSG00000181090

ENSEMBL

ENST00000462484, ENSP00000417328, ENSP00000485945, ENSP00000417980, ENSG00000181090, ENST00000371394, ENST00000460843

HPA

ENSG00000181090-EHMT1

GeneCards

EHMT1

ZINC target

Q9H9B1

PRO

Q9H9B1

Pharos - Targets

Q9H9B1

Orphanet

EHMT1

GlyGen

Q9H9B1

HMDB Protein

HMDBP00425

PDB

6MBP, 6MBO, 8XPT, 7T7M, 3SW9, 3MO2, 3MO0, 5VSF, 3SWC, 3FPD, 3B7B, 5VSD, 6BY9, 5V9J, 5TTG, 4I51, 5TUZ, 3B95, 3HNA, 2RFI, 2IGQ, 3MO5

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.725	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	4
UniProt:Q04207	7	Rela [nucleoplasm] (R-MMU-177676) Rela [cytosol] (R-MMU-168172) phospho-Rela [nucleoplasm] (R-MMU-5624468) phospho-Rela [nucleoplasm] (R-MMU-5660642) Rela [nucleoplasm] (R-MMU-4755466) phospho-Rela [nucleoplasm] (R-MMU-9861499) Rela [nucleoplasm] (R-MMU-8865233)	0.675	5
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.643	5
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.643	3
UniProt:Q9D752	1	Mad2l2 [nucleoplasm] (R-MMU-59092)	0.564	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.527	2
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	2
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.499	3