Reactome | EZH1 [nucleoplasm]

EZH1 [nucleoplasm]

Stable Identifier

R-HSA-1183229

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase EZH1, EZH1_HUMAN

Locations in the PathwayBrowser

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General

Catalytic subunit of the PRC2/EED-EZH1 complex

External Reference Information

External Reference

UniProt:Q92800 EZH1

Gene Names

EZH1, KIAA0388

Chain

chain:1-747

Reference Genes

BioGPS Gene:2145 EZH1

COSMIC (genes):EZH1 EZH1

CTD Gene:2145 EZH1

dbSNP Gene:2145 EZH1

ENSEMBL:ENSG00000108799 EZH1

HGNC:3526 EZH1

KEGG:hsa:2145 EZH1

Monarch:2145 EZH1

NCBI Gene:2145 EZH1

OMIM:601674 EZH1

UCSC:Q92800 EZH1

Reference Transcript

Other Identifiers

11717323_a_at

11717324_at

11763781_a_at

16845222

203249_3p_at

203249_PM_at

203249_at

211310_3p_at

211310_PM_at

211310_at

2145

239197_PM_s_at

239197_s_at

239198_PM_at

239198_at

32259_PM_at

32259_at

3758071

3758077

3758079

3758080

3758081

3758082

3758083

3758084

3758085

3758086

3758087

3758089

3758090

3758092

3758093

3758094

3758095

3758096

3758097

3758098

3758099

3758100

3758101

3758103

3758104

3758105

3758107

46841_at

8015685

A_23_P428219

GE62570

GE81100

GO:0000122

GO:0000781

GO:0000792

GO:0003682

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006355

GO:0008168

GO:0009653

GO:0016279

GO:0016740

GO:0021766

GO:0031491

GO:0031507

GO:0031509

GO:0032259

GO:0035098

GO:0042054

GO:0042393

GO:0045944

GO:0046976

GO:0048856

GO:0060090

GO:0140096

GO:0140693

GO:0140951

HMNXSV003053645

Hs.47564.0.S1_3p_at

ILMN_1791436

PH_hs_0011495

TC17001540.hg

U50315_at

g2224716_3p_at

g2224716_3p_s_at

g2934699_3p_x_at

Participates

as a component of

PRC2 (EZH1) core [nucleoplasm] (Homo sapiens)

Inferred To

EZH1 [nucleoplasm] (Bos taurus)

EZH1 [nucleoplasm] (Canis familiaris)

EZH1 [nucleoplasm] (Gallus gallus)

EZH1 [nucleoplasm] (Sus scrofa)

ezh2 [nucleoplasm] (Danio rerio)

ezh1 [nucleoplasm] (Danio rerio)

ezh1 [nucleoplasm] (Xenopus tropicalis)

Ezh1 [nucleoplasm] (Mus musculus)

Ezh1 [nucleoplasm] (Rattus norvegicus)

Homologues of EZH1 [nucleoplasm] (Danio rerio)

E(z) [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001982.2, NP_001308008.1, NP_001308010.1, NP_001308011.1

ZINC - World Drugs

EZH1_HUMAN

Guide to Pharmacology - Targets

2835

OpenTargets

ENSG00000108799

ENSEMBL

ENST00000590078, ENST00000592743, ENSP00000466924, ENST00000428826, ENSP00000404658, ENSP00000467871, ENSP00000465220, ENSG00000108799, ENST00000585893

ZINC - Substances

EZH1_HUMAN

ZINC - Biogenic

EZH1_HUMAN

ZINC target

Q92800

PRO

Q92800

PDB

7KSR, 7KSO, 7KTP, 7TD5

ZINC - Metabolites

EZH1_HUMAN

HPA

ENSG00000108799-EZH1

GeneCards

EZH1

Pharos - Targets

Q92800

ZINC - Predictions - Purchasable

EZH1_HUMAN

HMDB Protein

HMDBP09944

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.738	5
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	4
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.725	6
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.643	3
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2