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WHSC1L1 [nucleoplasm]
Stable Identifier
R-HSA-1183230
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase NSD3, NSD3, KMT3F, WHISTLE
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
WHSC1L1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BZ95 NSD3
Gene Names
NSD3, WHSC1L1, DC28
Chain
chain:1-1437
Reference Genes
BioGPS Gene:54904 NSD3
COSMIC (genes):NSD3 NSD3
CTD Gene:54904 NSD3
dbSNP Gene:54904 NSD3
ENSEMBL:ENSG00000147548 NSD3
ENSEMBL:ENSG00000147548.17 NSD3
HGNC:12767 NSD3
KEGG Gene (Homo sapiens):54904 NSD3
Monarch:54904 NSD3
NCBI Gene:54904 NSD3
OMIM:607083 NSD3
UCSC:Q9BZ95 NSD3
Reference Transcript
RefSeq:NM_023034.1 NSD3
RefSeq:NM_017778.2 NSD3
Other Identifiers
11721060_a_at
11730681_at
11730682_s_at
11741440_x_at
11754226_a_at
11754227_s_at
11755275_a_at
11755442_a_at
17076346
17076372
218173_PM_s_at
218173_s_at
221248_PM_s_at
221248_s_at
222544_PM_s_at
222544_s_at
223568_PM_s_at
223568_s_at
223569_PM_at
223569_at
224076_PM_s_at
224076_s_at
225318_PM_at
225318_at
226150_PM_at
226150_at
3131882
3131883
3131884
3131885
3131886
3131887
3131888
3131889
3131890
3131891
3131892
3131893
3131894
3131895
3131896
3131897
3131898
3131899
3131900
3131901
3131902
3131903
3131904
3131905
3131906
3131907
3131908
3131909
3131910
3131911
3131912
3131914
3131915
3131917
3131918
3131919
3131920
3131921
3131922
3131925
3131929
3131932
3131933
3131934
3131938
3131942
3131945
3131946
3131948
3131949
3131950
3131951
3131952
3131953
3131954
3131955
3131957
3131961
3131962
3131964
3131965
3131966
3131968
3131969
3131970
3131971
3131972
3131973
3131974
3131975
3131986
3131987
3131988
3758591
3758593
3758605
42709_at
45738_at
54721_at
54722_at
54904
64074_at
8150276
8150287
A_23_P216132
A_23_P329971
A_24_P106839
A_24_P317719
A_33_P3359219
GE55457
GE87495
GO:0000785
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008168
GO:0016740
GO:0018024
GO:0032259
GO:0043226
GO:0045893
GO:0046872
GO:0046975
GO:0098772
GO:0140096
GO:0140537
GO:0140946
GO:0140952
HMNXSV003009261
HMNXSV003014346
Hs.169341.1.S1_3p_at
Hs.27721.0.A1_3p_s_at
Hs.28274.0.S1_3p_at
ILMN_1666715
ILMN_1675406
ILMN_1697919
ILMN_1807379
PH_hs_0025031
PH_hs_0025582
TC08001144.hg
TC08001145.hg
TC08002292.hg
g12005822_3p_a_at
g13182756_3p_at
g13699810_3p_s_at
g13699812_3p_a_at
Participates
as a member of
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Inferred To
nsd3 [nucleoplasm]
(Xenopus tropicalis)
NSD3 [nucleoplasm]
(Bos taurus)
WHSC1L1 [nucleoplasm]
(Canis familiaris)
WHSC1L1 [nucleoplasm]
(Danio rerio)
WHSC1L1 [nucleoplasm]
(Sus scrofa)
Nsd3 [nucleoplasm]
(Mus musculus)
Nsd3 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_060248.2
,
NP_075447.1
OpenTargets
ENSG00000147548
IntEnz
2.1.1.371
,
2.1.1.370
HPA
ENSG00000147548-NSD3
GeneCards
Q9BZ95
Ensembl
ENSP00000313983
,
ENSP00000313410
,
ENST00000433384
,
ENST00000317025
,
ENST00000316985
,
ENSP00000393284
,
ENSP00000434730
,
ENSG00000147548
,
ENST00000527502
PRO
Q9BZ95
Pharos - Targets
Q9BZ95
HMDB Protein
HMDBP09023
PDB
6CEN
,
4GNF
,
5UPD
,
4GNG
,
6G29
,
7CRP
,
6G2O
,
6G27
,
4GND
,
4GNE
,
6G25
,
7JYN
,
6G3T
,
6G2F
,
6G24
,
6G2E
,
2NCZ
,
2ND1
,
6G2C
,
2DAQ
,
4RXJ
,
6G3P
,
7CRR
,
6G2B
,
7CRQ
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.573
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.547
3
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.543
4
UniProt:O95391 SLU7
1
hSLU7 [nucleoplasm]
(R-HSA-72073)
0.508
2
UniProt:Q13315 ATM
5
ATM [nucleoplasm]
(R-HSA-69484)
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.508
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.508
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.508
2
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