Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

COSMIC (genes):EGFR EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

Participates

as an input of

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 (Homo sapiens)

as a component of

EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR A767_V769dup [plasma membrane]

p-6Y-EGFR N771_H773dup [plasma membrane]

p-6Y-EGFR K739_I744dup [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR K739_I744dup [plasma membrane]

EGFR A767_V769dup [plasma membrane]

EGFR N771_H773dup [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

EGFR E746_A750del [plasma membrane]

p-6Y-EGFR [plasma membrane]

p-Y1086,Y1101-EGFR [plasma membrane]

EGFR [plasma membrane]

p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]

EGFR [endosome membrane]

p-4Y-EGFR [plasma membrane]

EGFR L747_S752del [plasma membrane]

EGFR G598V [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G719C [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR A289T [plasma membrane]

EGFR G719A [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
brain glioma	DOID:0060108
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
astrocytoma	DOID:3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma

Cross References

COSMIC

COSM21351

Interactors (324)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.983	59
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.981	29
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.976	44
UniProt:P01133 EGF	5	EGF [extracellular region] (R-HSA-179863) Pro-EGF [plasma membrane] (R-HSA-179888) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) Pro-EGF [extracellular region] (R-HSA-54209) EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086)	0.973	29
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.964	26
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.954	25
UniProt:P21860 ERBB3			0.919	14
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.919	15
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.9	9
UniProt:Q9UJM3 ERRFI			0.9	15
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.898	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.89	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.854	7
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.85	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
UniProt:P62158 CALM			0.828	6
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.828	8
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.823	6
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.821	8
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.82	7
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.819	6
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.813	7
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.811	10
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.81	7
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.809	12
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.807	5
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.803	7
UniProt:P20417	2	PTPN1 [cytosol] (R-RNO-210625) PTPN1 [endosome membrane] (R-RNO-9815895)	0.802	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.8	8
UniProt:P08107 HSP71			0.799	6
UniProt:Q92625 ANS1A			0.793	7
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.793	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.786	13
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.785	7
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.785	5
UniProt:P01135 TGFA	5	TGFA(24-98) [extracellular region] (R-HSA-9624183) TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840) TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817)	0.779	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.778	7
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.774	7
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.773	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.772	6
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.772	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.76	7
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.76	5
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.749	5
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.745	4
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.745	5
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.745	7
UniProt:P38646 HSPA9	6	HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.745	5
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.743	6
UniProt:P26447 S10A4			0.743	6
UniProt:Q92870 APBB2			0.737	7
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.737	4
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.735	4
UniProt:Q13480 GAB1	4	p-Y-GAB1 [cytosol] (R-HSA-8855306) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.735	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.735	4
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.729	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.713	4
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.713	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.695	4
UniProt:Q13387 JIP2			0.692	5
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
UniProt:P23467 PTPRB	3	PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.692	3
UniProt:P43403 ZAP70	3	p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252) p-Y493-ZAP70 [cytosol] (R-HSA-202368) ZAP70 [cytosol] (R-HSA-202397)	0.692	3
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.692	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.692	3
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
UniProt:Q8TF42 UBS3B			0.69	7
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.683	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.683	4
UniProt:Q99962 SH3GL2	4	SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.681	4
UniProt:O75368 SH3L1			0.681	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.681	3
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-167992) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646)	0.681	3
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.68	5
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.679	11
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [endocytic vesicle membrane] (R-HSA-416641)	0.671	6
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.669	3
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.669	3
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.668	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.668	3
UniProt:Q09666 AHNK			0.667	4
UniProt:P51636 CAV2	2	CAV2 [plasma membrane] (R-HSA-9021035) CAV2 [Golgi membrane] (R-HSA-9021032)	0.667	3
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.667	3
UniProt:Q9NZM3 ITSN2	1	ITSN2 [cytosol] (R-HSA-8862264)	0.653	3
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.653	3
UniProt:P14923 JUP	6	JUP [plasma membrane] (R-HSA-437260) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739) JUP [cytosol] (R-HSA-201598)	0.653	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.653	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.653	3
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.649	4
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.643	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.635	3
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.635	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
UniProt:Q9Y2H9 MAST1			0.635	3
UniProt:P42229 STAT5A	4	STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [cytosol] (R-HSA-507936) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.635	4
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) PRKCA [plasma membrane] (R-HSA-156469) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.635	3
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.635	3
UniProt:Q6S5L8 SHC4			0.635	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.635	3
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.635	3
UniProt:Q9BRG2 SH23A			0.635	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.635	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.635	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.635	4
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.635	3
UniProt:P09769 FGR	3	FGR [cytosol] (R-HSA-432116) FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524)	0.635	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.635	4
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.628	7
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.623	3
UniProt:Q12852 M3K12			0.621	3
UniProt:Q6UW88 EPGN	2	EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815) EPGN(23-154) [extracellular region] (R-HSA-9624187)	0.618	3
UniProt:O14944 EREG	2	EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816) EREG(60-108) [extracellular region] (R-HSA-1233233)	0.618	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.615	3
UniProt:Q99075 HBEGF	8	HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.609	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [early endosome membrane] (R-HSA-2029032) RABGEF1 [cytosol] (R-HSA-8875419)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	6
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.592	2
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.591	3
UniProt:Q8IZW8 TNS4	1	TNS4 [cytosol] (R-HSA-201624)	0.59	2
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667)	0.583	4
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.583	3
UniProt:P29353-7 SHC1			0.581	4
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.581	4
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.576	8
UniProt:P23470 PTPRG			0.573	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.571	3
UniProt:Q9Y6R0 NUMBL			0.571	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.571	2
UniProt:P07992 ERCC1	2	Ub-ERCC1 [nucleoplasm] (R-HSA-5696473) ERCC1 [nucleoplasm] (R-HSA-54427)	0.571	21
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166) AP2B1 [plasma membrane] (R-HSA-167690)	0.569	5
UniProt:P53680 AP2S1	4	AP2S1 [endolysosome membrane] (R-HSA-6784821) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [cytosol] (R-HSA-182197) AP2S1 [plasma membrane] (R-HSA-389382)	0.569	3
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155) AP2A2(1-939) [plasma membrane] (R-HSA-177502)	0.569	4
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.569	3
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.569	3
UniProt:Q92622 RUBIC			0.564	3
UniProt:Q15303 ERBB4			0.564	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.564	2
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.564	5
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:O75674 TM1L1			0.556	6
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.553	2
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342)	0.553	2
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.553	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.553	2
UniProt:Q9H299 SH3L3			0.553	2
UniProt:Q8N111 CEND			0.553	2
UniProt:Q59GR8 Q59GR8			0.553	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.553	2
UniProt:P16930 FAH	1	FAH [cytosol] (R-HSA-71174)	0.553	2
UniProt:Q59G22 Q59G22			0.553	2
UniProt:Q13491 GPM6B			0.553	2
UniProt:A4FU49 SH321			0.553	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.553	2
UniProt:O95433 AHSA1			0.553	2
UniProt:Q7L273 KCTD9			0.553	2
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.553	2
UniProt:O15511 ARPC5	4	ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [cytosol] (R-HSA-200806)	0.553	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.553	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.553	2
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.553	2
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.553	2
UniProt:P06132 UROD	1	UROD [cytosol] (R-HSA-189427)	0.553	2
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [extracellular region] (R-HSA-349735) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [cytosol] (R-HSA-71492)	0.553	2
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
UniProt:Q8TDI0 CHD5			0.553	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.553	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.553	2
UniProt:Q8N2Y8 RUSC2			0.553	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.553	2
UniProt:Q53GZ6 Q53GZ6			0.553	2
UniProt:P17600 SYN1	2	SYN1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659624) SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577)	0.553	2
UniProt:P31939 ATIC	5	ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710833) ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710847) ATIC(1-230)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710832) ATIC(1-229)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710829) ATIC [cytosol] (R-HSA-62506)	0.553	2
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.553	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.553	2
UniProt:Q9UPY6 WASF3	3	p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385) p-Y151-WASF3 [cytosol] (R-HSA-2029006) WASF3 [cytosol] (R-HSA-200975)	0.553	2
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.553	2
UniProt:Q9NNZ3 DNJC4			0.553	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.553	2
UniProt:Q14050 COL9A3	20	GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198) GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210) 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209) COL9A3 [extracellular region] (R-HSA-375063) 3Hyp-4Hyp-COL9A3 [extracellular region] (R-HSA-2193009) GalHyl-COL9A3 [extracellular region] (R-HSA-2192976) 3x4Hyp-COL9A3 [extracellular region] (R-HSA-2192931) 3x4Hyp-3Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2192946) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192978) GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192962) 3x4Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193029) 3x4Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192981) 3x4Hyp-3Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193030) 3x4Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2193003) 5Hyl-COL9A3 [extracellular region] (R-HSA-2193022) 3x4Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470434) 3x4Hyp-3Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470413) 3x4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470381) GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470412)	0.553	2
UniProt:O94992 HEXI1			0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.553	2
UniProt:Q9Y3A3 PHOCN			0.553	2
UniProt:Q96AD5 PNPLA2	4	PNPLA2 [lipid droplet] (R-HSA-9859603) p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923) PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776) PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814)	0.553	2
UniProt:O94875 SRBS2			0.553	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.553	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [cytosol] (R-HSA-947624) UBE2V2 [nucleoplasm] (R-HSA-5682543)	0.553	2
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.553	2
UniProt:Q6UWJ1 TMCO3			0.553	2
UniProt:Q99784 NOE1			0.553	2
UniProt:Q92918 M4K1			0.553	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.553	2
UniProt:P49798 RGS4	1	RGS4 [plasma membrane] (R-HSA-921135)	0.553	2
UniProt:O75095 MEGF6			0.553	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.553	2
UniProt:O43707 ACTN4	3	ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [cytosol] (R-HSA-390558)	0.553	2
UniProt:Q8N5H7 SH2D3			0.553	2
UniProt:Q02297 NRG1	1	NRG1 [extracellular region] (R-HSA-1227951)	0.553	2
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.553	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.553	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.553	2
UniProt:Q92733 PRCC	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.553	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.553	2
UniProt:Q59EJ3 Q59EJ3			0.553	2
UniProt:P43243 MATR3			0.553	2
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.553	2
UniProt:P49908 SELENOP	2	SEPP1 [extracellular region] (R-HSA-8848887) SEPP1 [platelet dense granule lumen] (R-HSA-8848897)	0.553	2
UniProt:Q8TDB4 HUMMR			0.553	2
UniProt:Q02156 PRKCE	2	p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260) PRKCE [cytosol] (R-HSA-58202)	0.553	2
UniProt:Q9Y237 PIN4			0.553	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.553	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.553	2
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142)	0.553	2
UniProt:P20336 RAB3A	9	RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [cytosol] (R-HSA-8870410) GGC-RAB3A [cytosol] (R-HSA-8870429) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.553	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.553	2
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [plasma membrane] (R-HSA-2029017)	0.553	2
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.553	2
UniProt:P21291 CSRP1	1	CSRP1 [nucleoplasm] (R-HSA-5660398)	0.553	2
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.553	2
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.553	2
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.553	2
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.553	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.553	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.553	2
UniProt:P30307 CDC25C	8	p-S198-CDC25C [nucleoplasm] (R-HSA-156668) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [cytosol] (R-HSA-157879) CDC25C [nucleoplasm] (R-HSA-69741) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.553	2
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.553	2
UniProt:P26641 EEF1G	3	EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G [cytosol] (R-HSA-156925)	0.553	2
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.553	2
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.553	2
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.553	2
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.553	2
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.553	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.553	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.553	2
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.553	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.553	2
UniProt:Q16620 NTRK2	6	p-5Y-NTRK2 [plasma membrane] (R-HSA-9026475) NTRK2 [plasma membrane] (R-HSA-6798236) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044) NTRK2 [Golgi membrane] (R-HSA-3008801) p-5Y-NTRK2 [Golgi membrane] (R-HSA-3008809) p-5Y,S479-NTRK2 [plasma membrane] (R-HSA-9032864)	0.553	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.553	2
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.553	2
UniProt:P11309 PIM1	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.553	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.553	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.553	2
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.553	2
UniProt:P10586 PTPRF	2	PTPRF [endosome membrane] (R-HSA-9815889) PTPRF [plasma membrane] (R-HSA-6786486)	0.547	2
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.547	2
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.547	2
UniProt:Q14956-1 GPNMB			0.544	2
UniProt:P07948-1 LYN			0.544	2
UniProt:Q38SD2 LRRK1			0.544	2
UniProt:P17936 IGFBP3	15	IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454)	0.539	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.537	4
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.536	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:P55060 XPO2			0.527	2
UniProt:Q6XE38 SG1D4			0.527	2
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2
UniProt:Q00325 S25A3			0.527	3
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	2
UniProt:O00483 NDUFA4	1	NDUFA4 [mitochondrial inner membrane] (R-HSA-60617)	0.527	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	5
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.527	2
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.527	5
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.527	2
UniProt:P62161 CALM			0.524	6
UniProt:P03372-4 ESR1	4	PalmS-ER alpha36 [cytosol] (R-HSA-9020988) PalmS-ER alpha36 [plasma membrane] (R-HSA-9021053) Me87-PalmS-ER alpha36 [plasma membrane] (R-HSA-9637786) ER alpha36 [cytosol] (R-HSA-9020981)	0.524	4
UniProt:Q14956 GPNMB	2	p-Y525-GPNMB [plasma membrane] (R-HSA-8857558) GPNMB [plasma membrane] (R-HSA-8857550)	0.524	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.524	2
UniProt:P13866 SLC5A1	8	SLC5A1 [plasma membrane] (R-HSA-189243) SLC5A1 Y191* [plasma membrane] (R-HSA-5656372) SLC5A1 G100V [plasma membrane] (R-HSA-5656373) SLC5A1 Q457R [plasma membrane] (R-HSA-5656354) SLC5A1 R379* [plasma membrane] (R-HSA-5656370) SLC5A1 D28G [plasma membrane] (R-HSA-5656368) SLC5A1 R135W [plasma membrane] (R-HSA-5656381) SLC5A1 D28N [plasma membrane] (R-HSA-5656362)	0.524	3
UniProt:P97313	4	Prkdc [cytosol] (R-MMU-8938766) Prkdc [cytosol] (R-MMU-3134816) Prkdc [nucleoplasm] (R-MMU-62161) phospho-Prkdc [nucleoplasm] (R-MMU-76302)	0.518	4
UniProt:P46108-1 CRK			0.508	3
UniProt:Q9BRK4 LZTS2			0.508	2
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.508	2
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.508	2
UniProt:Q8WXI2 CNKSR2	1	CNKSR2 [cytosol] (R-HSA-5672632)	0.508	2
UniProt:Q9HD43 PTPRH			0.508	3
UniProt:O75563 SKAP2	1	SKAP2 [cytosol] (R-HSA-390927)	0.508	2
UniProt:Q7L591 DOK3	3	DOK3 [secretory granule membrane] (R-HSA-6801402) DOK3 [plasma membrane] (R-HSA-6801572) DOK3 [ficolin-1-rich granule membrane] (R-HSA-6801409)	0.508	2
UniProt:Q9NS73 MBIP	1	MBIP [nucleoplasm] (R-HSA-3662291)	0.508	2
UniProt:Q8TEY7 USP33