Reactome | Me2K5-H3F3A [nucleoplasm]

Me2K5-H3F3A [nucleoplasm]

Stable Identifier

R-HSA-1214206

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.3 with dimethylated lysine-4, H3F3A, H33_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)
        
        Me2K5-H3F3A [nucleoplasm] (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)
        
        Me2K5-H3F3A [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive CCND1 gene expression (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)
        
        Me2K5-H3F3A [nucleoplasm] (Homo sapiens)
      - FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)
        
        Me2K5-H3F3A [nucleoplasm] (Homo sapiens)
        
        CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)
        
        Me2K5-H3F3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P84243 H3-3A

Gene Names

H3-3A, H3.3A, H3F3, H3F3A, PP781, H3-3B, H3.3B, H3F3B

Chain

initiator methionine:, chain:2-136

Reference Genes

BioGPS Gene:3020 H3-3A

BioGPS Gene:3021 H3-3A

CTD Gene:3020 H3-3A

CTD Gene:3021 H3-3A

dbSNP Gene:3020 H3-3A

dbSNP Gene:3021 H3-3A

ENSEMBL:ENSG00000132475 H3F3B

ENSEMBL:ENSG00000163041 H3F3A

ENSEMBL_homo_sapiens_GENE:ENSG00000132475.10 H3-3A

ENSEMBL_homo_sapiens_GENE:ENSG00000163041.13 H3-3A

HGNC:4764 H3-3A

HGNC:4765 H3-3A

KEGG Gene (Homo sapiens):3020 H3-3A

KEGG Gene (Homo sapiens):3021 H3-3A

Monarch:3020 H3-3A

Monarch:3021 H3-3A

NCBI Gene:3020 H3-3A

NCBI Gene:3021 H3-3A

OMIM:601058 H3-3A

OMIM:601128 H3-3A

UCSC:P84243 H3-3A

Reference Transcript

Other Identifiers

11715189_s_at

11739481_x_at

11754775_s_at

11756379_x_at

11757037_s_at

11757038_x_at

11758593_s_at

16650285

16650289

16650291

16650293

16650295

16848888

16887898

18670604

18670605

18670606

200080_PM_s_at

200080_s_at

208755_PM_x_at

208755_x_at

209069_PM_s_at

209069_s_at

211940_PM_x_at

211940_x_at

211997_PM_x_at

211997_x_at

211998_PM_at

211998_at

211999_PM_at

211999_at

213828_PM_x_at

213828_x_at

2383063

2383064

2383065

2383067

2383068

2383069

2383070

2383071

2383075

2383076

2383077

2383078

2383079

2383080

2516451

2516452

2516453

2516454

2516455

254_at

2739999

2740001

2740002

2786723

2786725

2786727

2786729

3020

3021

31510_s_at

3449959

3493224

3493226

3493227

3770943

3770945

3770946

3770947

3770948

3770949

3770950

3770951

3770952

3770954

3770955

3770957

3770958

3770959

3770961

3989613

3989617

3989619

3989621

4003653

73099_at

7894282

7895579

7896511

7910124

8018439

8046515

8102860

8169740

90048_at

A_14_P138929

A_23_P152516

A_23_P23141

A_24_P105298

A_24_P82419

A_24_P91035

A_32_P208424

A_33_P3410194

GE80224

GE80274

GO:0000781

GO:0000786

GO:0000978

GO:0000979

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0030307

GO:0030527

GO:0031492

GO:0032200

GO:0032991

GO:0043226

GO:0043229

GO:0046982

GO:0065003

GO:0070062

HMNXSV003016235

HMNXSV003029246

HMNXSV003033897

Hs.180877.1.A1_3p_s_at

Hs.180877.1.A3_3p_at

Hs.180877.1.A4_3p_at

Hs.181307.4.A1_3p_a_at

ILMN_1656082

ILMN_1695706

ILMN_1699015

ILMN_2106331

ILMN_2402930

ILMN_2402936

M11353_at

PH_hs_0027287

PH_hs_0032025

PH_hs_0040066

TC01001857.hg

TC01005067.hg

TC17001882.hg

X05855_s_at

Z48950_at

g12654576_3p_s_at

Participates

as a candidate of

H3K4me2 [nucleoplasm] (Homo sapiens)

as a member of

Histone H3 (H3K4me2) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MeK-H3F3A [nucleoplasm]

2xAcK-H3F3A [nucleoplasm]

MeK28-H3-3A [nucleoplasm]

H3R17me2a [nucleoplasm]

Me2K5,Me2aR2-H3F3A [nucleoplasm]

AcK10-H3F3A [nucleoplasm]

H3F3A [extracellular region]

Me3K5-H3F3A [nucleoplasm]

Me2K-10-H3F3A [nucleoplasm]

p-T12-H3F3A [nucleoplasm]

p-T12,MeK-H3F3A [nucleoplasm]

p-T12, Me2K-10-H3F3A [nucleoplasm]

p-T12,Me3K-10-H3F3A [nucleoplasm]

Me3K-10-H3F3A [nucleoplasm]

Me3K-28-H3F3A [nucleoplasm]

H3F3A [nucleoplasm]

Inferred To

hht1 [nucleoplasm] (Schizosaccharomyces pombe)

h3f3b.1 [nucleoplasm] (Danio rerio)

HHT2 [nucleoplasm] (Saccharomyces cerevisiae)

H3-X [nucleoplasm] (Gallus gallus)

His3.3A [nucleoplasm] (Drosophila melanogaster)

Homologues of Me2K5-H3F3A [nucleoplasm] (Drosophila melanogaster)

Homologues of Me2K5-H3F3A [nucleoplasm] (Schizosaccharomyces pombe)

H3-3A [nucleoplasm] (Sus scrofa)

His3.3B [nucleoplasm] (Drosophila melanogaster)

hht3 [nucleoplasm] (Schizosaccharomyces pombe)

his-71 [nucleoplasm] (Caenorhabditis elegans)

Me2K5-H3F3A [nucleoplasm] (Bos taurus)

H3-3b [nucleoplasm] (Mus musculus)

H3-3b [nucleoplasm] (Rattus norvegicus)

LOC612779 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 5

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_005315.1, NP_002098.1

OpenTargets

ENSG00000163041

GeneCards

P84243

HPA

ENSG00000132475-H3-3B, ENSG00000163041-H3-3A

Ensembl

ENSP00000499385, ENST00000366816, ENSP00000355778, ENST00000655399, ENSP00000499800, ENSP00000254810, ENSP00000466020, ENSP00000499275, ENSP00000465813, ENSG00000163041, ENST00000661429, ENST00000366815, ENST00000666609, ENSP00000468714, ENSG00000132475, ENST00000366813, ENSP00000355781, ENSP00000355780, ENST00000587560, ENST00000589599, ENST00000254810, ENST00000586607

PRO

P84243

Pharos - Targets

P84243

PDB

7XTI, 4GNF, 6J4X, 7CWH, 7WBX, 6J4W, 5KDM, 5JA4, 6IR9, 4GNE, 7V1L, 6A5U, 4H9S, 5DX0, 3JVK, 7V1M, 6RNY, 4L58, 6U04, 6HGT, 6A5T, 6R0C, 4H9R, 5B33, 4U7T, 6A5R, 4N4I, 3WTP, 4H9Q, 4QQ4, 5BNX, 7OKP, 7A08, 5BNV, 3QLC, 4O62, 2L43, 3QLA, 6INQ, 6J51, 6A5L, 5X7X, 4TMP, 3ASL, 3ASK, 7XSE, 4GNG, 5JJY, 8JH2, 7VCQ, 5DWQ, 7CJ0, 4GUR, 4GUS, 7W5M, 8JH4, 8JH3, 7CIZ, 3MUK, 5JLB, 7XSX, 3MUL, 5B32, 6J9J, 7XSZ, 4H9P, 4H9O, 7XT7, 6A5P, 4W5A, 4GY5, 4HGA, 4H9N, 6A5O, 6PZV, 7XTD, 3AV2, 6J4Z, 7WBV, 6J4Y, 6J50, 4GU0, 6QXZ, 7WBW, 3QL9

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.861	12
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.85	8
UniProt:Q9UER7-1 DAXX			0.781	21
UniProt:Q9NVP2 ASF1B			0.723	5
UniProt:Q8R5C8 ZMY11			0.691	6
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.667	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.656	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	3
UniProt:P54198 HIRA	1	HIRA [nucleoplasm] (R-HSA-2532790)	0.643	3
UniProt:Q13111 CAF1A			0.623	3
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.618	7
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.597	5
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.597	7
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.591	11
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.564	2
UniProt:P49321-2 NASP			0.556	3
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.547	2
UniProt:Q5VWG9 TAF3	1	TAF3 [nucleoplasm] (R-HSA-212446)	0.544	3
UniProt:Q13112 CAF1B			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q8IV20 LACC1			0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	2
UniProt:Q9Y496 KIF3A	3	KIF3A [cilium] (R-HSA-5610394) KIF3A [cytosol] (R-HSA-984767) KIF3A [ciliary tip] (R-HSA-5625377)	0.527	2
UniProt:Q8WVS4 DYNC2I1	2	WDR60 [ciliary tip] (R-HSA-5625409) WDR60 [cilium] (R-HSA-5624903)	0.508	2
UniProt:Q96EX3 DYNC2I2	2	WDR34 [ciliary tip] (R-HSA-5625407) WDR34 [cilium] (R-HSA-5624900)	0.508	2
UniProt:C4QZQ7 C4QZQ7			0.495	2

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