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What is Reactome ?
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Table of Contents
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CDC37 [cytosol]
Stable Identifier
R-HSA-1221609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CDC37A, HSP90 co-chaperone CDC37
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)
EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 homodimerization (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Drug resistance in ERBB2 KD mutants (Homo sapiens)
Resistance of ERBB2 KD mutants to AEE788 (Homo sapiens)
Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)
ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to afatinib (Homo sapiens)
ERBB2 T798M does not bind afatinib (Homo sapiens)
ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to lapatinib (Homo sapiens)
Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)
ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to neratinib (Homo sapiens)
Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)
ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to osimertinib (Homo sapiens)
ERBB2 KD mutants do not bind osimertinib (Homo sapiens)
ERBB2 KD mutants (osimertinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to sapitinib (Homo sapiens)
ERBB2 T862A does not bind sapitinib (Homo sapiens)
ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to tesevatinib (Homo sapiens)
ERBB2 T733I does not bind tesevatinib (Homo sapiens)
ERBB2 T733I:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)
Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Drug resistance in ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)
ERBB2 TMD/JMD mutants (pertuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
ERBB2 ECD mutants bind TKIs (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants bind trastuzumab (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind TKIs (Homo sapiens)
ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants bind trastuzumab (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants heterodimerize (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):TKI:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)
ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 R678Q:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)
ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
MLKL:HSP90:CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
RIPK3 binds HSP90:CDC37 (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
RIPK3:HSP90:CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 binds pertuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds GTP (Homo sapiens)
HSP90:CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16543 CDC37
Gene Names
CDC37, CDC37A
Chain
chain:1-378, initiator methionine:, chain:2-378
Reference Genes
BioGPS Gene:11140 CDC37
COSMIC (genes):CDC37 CDC37
CTD Gene:11140 CDC37
dbSNP Gene:11140 CDC37
ENSEMBL:ENSG00000105401 CDC37
ENSEMBL_homo_sapiens_GENE:ENSG00000105401.9 CDC37
HGNC:1735 CDC37
KEGG Gene (Homo sapiens):11140 CDC37
Monarch:11140 CDC37
NCBI Gene:11140 CDC37
OMIM:605065 CDC37
UCSC:Q16543 CDC37
Reference Transcript
RefSeq:NM_007065.3 CDC37
Other Identifiers
11140
11715719_x_at
16868732
209953_PM_s_at
209953_s_at
2883688
3850332
3850333
3850335
3850336
3850337
3850338
3850340
3850341
3850344
3850346
3850347
505_at
8034021
A_23_P130531
GE80424
GO:0000079
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006457
GO:0006605
GO:0006886
GO:0006914
GO:0007005
GO:0010608
GO:0019887
GO:0019900
GO:0019901
GO:0023052
GO:0031072
GO:0036211
GO:0043226
GO:0050821
GO:0051082
GO:0051087
GO:0051879
GO:0060334
GO:0060338
GO:0070062
GO:0097110
GO:0098542
GO:0098772
GO:0098779
GO:0101031
GO:1990565
HMNXSV003020739
ILMN_1668369
PH_hs_0009781
TC19001165.hg
U43077_at
g1421820_3p_a_at
Participates
as a component of
HSP90:CDC37 [cytosol] (Homo sapiens)
CDC37 [cytosol] (Homo sapiens)
Inferred To
Cdc37 [cytosol]
(Drosophila melanogaster)
Cdc37 [cytosol]
(Mus musculus)
Cdc37 [cytosol]
(Rattus norvegicus)
cdc37 [cytosol]
(Danio rerio)
cdc37 [cytosol]
(Schizosaccharomyces pombe)
cdc37 [cytosol]
(Xenopus tropicalis)
cdc-37 [cytosol]
(Caenorhabditis elegans)
CDC37 [cytosol]
(Bos taurus)
CDC37 [cytosol]
(Canis familiaris)
CDC37 [cytosol]
(Gallus gallus)
CDC37 [cytosol]
(Saccharomyces cerevisiae)
CDC37 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_008996.1
OpenTargets
ENSG00000105401
GeneCards
Q16543
HPA
ENSG00000105401-CDC37
Ensembl
ENSP00000222005
,
ENST00000222005
,
ENSG00000105401
PRO
Q16543
Pharos - Targets
Q16543
HMDB Protein
HMDBP08633
PDB
2K5B
,
7ZR5
,
8GFT
,
5FWL
,
5FWM
,
7Z38
,
2N5X
,
8GAE
,
5FWK
,
2NCA
,
5HPE
,
7ZR6
,
5FWP
,
7ZR0
,
1US7
,
7Z37
,
2W0G
Interactors (74)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.94
17
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.919
14
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.899
20
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.899
17
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.886
9
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.886
9
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.882
10
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.848
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.848
9
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.848
8
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.834
7
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
Active NIK [cytosol]
(R-HSA-5607646)
0.813
6
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.801
8
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.786
13
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.77
4
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.744
6
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.744
7
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.744
6
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.728
4
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.708
5
UniProt:P53041 PPP5C
2
PPP5C [cytosol]
(R-HSA-5675402)
PPP5C [nucleoplasm]
(R-HSA-5683410)
0.708
5
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.708
6
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.695
5
UniProt:Q9Y243 AKT3
6
p-T305-AKT3 [cytosol]
(R-HSA-3009370)
AKT3 [cytosol]
(R-HSA-2976007)
AKT3 [plasma membrane]
(R-HSA-2976006)
p-S472-AKT3 [plasma membrane]
(R-HSA-3009363)
p-T305,S472-AKT3 [cytosol]
(R-HSA-3009367)
p-T305,S472-AKT3 [nucleoplasm]
(R-HSA-3009365)
0.688
5
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.669
4
UniProt:P25685 DNAJB1
3
p-S149,S151,S171 DNAJB1 [cytosol]
(R-HSA-5690241)
DNAJB1 [cytosol]
(R-HSA-3299666)
DNAJB1 [nucleoplasm]
(R-HSA-5082366)
0.659
3
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.643
6
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.643
4
UniProt:Q9BQI3 EIF2AK1
3
p-T-EIF2AK1 [cytosol]
(R-HSA-9648892)
p-T,T486,T488-EIF2AK1 [cytosol]
(R-HSA-9648894)
EIF2AK1 [cytosol]
(R-HSA-9840382)
0.643
3
UniProt:O14757 CHEK1
3
CHEK1 [cytosol]
(R-HSA-205285)
CHEK1 [nucleoplasm]
(R-HSA-113826)
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
0.643
3
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.643
4
UniProt:Q08881 ITK
3
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
p-Y512-ITK [cytosol]
(R-HSA-422519)
ITK [cytosol]
(R-HSA-202319)
0.643
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
11
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.601
4
UniProt:O14879 IFIT3
1
IFIT3 [cytosol]
(R-HSA-947491)
0.582
4
UniProt:P29474 NOS3
7
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
NOS3 [cytosol]
(R-HSA-202114)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
0.582
4
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.569
5
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.569
5
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.569
3
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.569
4
UniProt:P34925 RYK
1
RYK [plasma membrane]
(R-HSA-3006746)
0.569
3
UniProt:Q6PHR2 ULK3
1
ULK3 [ciliary tip]
(R-HSA-5635039)
0.564
2
UniProt:Q14004 CDK13
3
CDK13 [extracellular region]
(R-HSA-6806442)
CDK13 [ficolin-1-rich granule lumen]
(R-HSA-6801374)
CDK13 [nucleoplasm]
(R-HSA-6797014)
0.564
2
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.564
2
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:Q6PIF2 SYCE2
1
SYCE2 [nucleoplasm]
(R-HSA-912451)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q6NZI2 PTRF
2
PTRF [nucleoplasm]
(R-HSA-74981)
CAVIN1 [plasma membrane]
(R-HSA-9714278)
0.556
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q8IZU3 SYCP3
1
SYCP3 [nucleoplasm]
(R-HSA-912329)
0.556
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.547
2
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.527
3
UniProt:P09769 FGR
3
FGR [extracellular region]
(R-HSA-6806524)
FGR [secretory granule lumen]
(R-HSA-6804974)
FGR [cytosol]
(R-HSA-432116)
0.527
3
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.527
2
UniProt:Q9H3Y6 SRMS
1
SRMS [cytosol]
(R-HSA-3902520)
0.527
3
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.527
2
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.527
2
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.527
3
UniProt:P19525 EIF2AK2
5
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
EIF2AK2 [cytosol]
(R-HSA-168699)
0.527
2
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.527
3
UniProt:Q06187 BTK
6
Active BTK [cytosol]
(R-HSA-8964323)
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
0.527
3
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.527
3
UniProt:Q13882 PTK6
5
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
0.499
4
UniProt:P33279 EIF2AK1
1
p-T-EIF2AK1 [cytosol]
(R-OCU-9655575)
0.499
3
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.499
3
UniProt:P02649 APOE
10
APOE [early endosome]
(R-HSA-2429687)
APOE [endosome lumen]
(R-HSA-174804)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
APOE [extracellular region]
(R-HSA-174646)
0.482
3
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