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LTF [phagocytic vesicle lumen]
Stable Identifier
R-HSA-1222567
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
Synonyms
Lactoferrin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Mtb iron assimilation by chelation (Homo sapiens)
Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)
2xCarboxymycobactin:2xFe3+:LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
2xCarboxymycobactin:LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-) (Homo sapiens)
2xCarboxymycobactin:LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)
2xCarboxymycobactin:2xFe3+:LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Metal sequestration by antimicrobial proteins (Homo sapiens)
Lactoferrin scavenges iron ions (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF [phagocytic vesicle lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02788 LTF
Gene Names
LTF, GIG12, LF
Chain
signal peptide:1-19, chain:20-710, peptide:20-67, peptide:171-201, peptide:338-343, peptide:543-547, peptide:680-686
Reference Genes
BioGPS Gene:4057 LTF
COSMIC (genes):LTF LTF
CTD Gene:4057 LTF
dbSNP Gene:4057 LTF
ENSEMBL:ENSG00000012223 LTF
ENSEMBL_homo_sapiens_GENE:ENSG00000012223.13 LTF
HGNC:6720 LTF
KEGG Gene (Homo sapiens):4057 LTF
Monarch:4057 LTF
NCBI Gene:4057 LTF
OMIM:150210 LTF
UCSC:P02788 LTF
Reference Transcript
RefSeq:NM_001321122.1 LTF
RefSeq:NM_001321121.1 LTF
RefSeq:NM_002343.5 LTF
RefSeq:NM_001199149.1 LTF
Other Identifiers
11723193_s_at
11755996_s_at
16952883
202018_PM_s_at
202018_s_at
2672146
2672147
2672150
2672152
2672153
2672156
2672160
2672162
2672163
2672164
2672165
2672166
2672167
2672169
2672170
2672171
2672172
2672175
2672176
2672177
2672178
37149_s_at
4047321
4047324
4047326
4047330
4047332
4047336
4047340
4047344
4047346
4047348
4047350
4047352
4047354
4047356
4057
8086607
A_23_P166848
GE61208
GO:0001503
GO:0001530
GO:0001817
GO:0002227
GO:0002376
GO:0003677
GO:0003824
GO:0004252
GO:0004869
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0006351
GO:0006355
GO:0006508
GO:0006811
GO:0006826
GO:0006959
GO:0008201
GO:0008233
GO:0008236
GO:0008289
GO:0009986
GO:0012501
GO:0016787
GO:0019731
GO:0019732
GO:0023052
GO:0030141
GO:0030154
GO:0031410
GO:0031640
GO:0031665
GO:0032680
GO:0032780
GO:0032991
GO:0033690
GO:0034145
GO:0035580
GO:0036211
GO:0042581
GO:0042742
GO:0043066
GO:0043123
GO:0043226
GO:0043539
GO:0044793
GO:0045071
GO:0045669
GO:0046872
GO:0048525
GO:0048856
GO:0050829
GO:0051092
GO:0055037
GO:0060349
GO:0061844
GO:0070062
GO:0071902
GO:0097013
GO:0098542
GO:0098772
GO:0140096
GO:0140912
GO:1900159
GO:1900229
GO:1902732
GO:1904724
GO:2000117
GO:2000308
GO:2001205
HMNXSV003002908
ILMN_1677920
PH_hs_0025606
PH_hs_0033411
TC03001357.hg
X53961_at
g4505042_3p_a_at
Participates
as a component of
LTF:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
LTF:2xFe3+:2xCO3(2-) [phagocytic vesicle lumen] (Homo sapiens)
as an input of
Lactoferrin scavenges iron ions (Homo sapiens)
Other forms of this molecule
LTF [specific granule lumen]
LTF [tertiary granule lumen]
LTF [extracellular region]
Inferred To
LTF [phagocytic vesicle lumen]
(Bos taurus)
LTF [phagocytic vesicle lumen]
(Canis familiaris)
LTF [phagocytic vesicle lumen]
(Drosophila melanogaster)
LTF [phagocytic vesicle lumen]
(Gallus gallus)
LTF [phagocytic vesicle lumen]
(Mus musculus)
LTF [phagocytic vesicle lumen]
(Sus scrofa)
LTF [phagocytic vesicle lumen]
(Xenopus tropicalis)
Tsf3 [phagocytic vesicle lumen]
(Drosophila melanogaster)
Homologues of LTF [phagocytic vesicle lumen]
(Drosophila melanogaster)
Tsf1 [phagocytic vesicle lumen]
(Drosophila melanogaster)
Ltf [phagocytic vesicle lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_001308050.1
,
NP_001308051.1
,
NP_001186078.1
,
NP_002334.2
OpenTargets
ENSG00000012223
HPA
ENSG00000012223-LTF
GeneCards
P02788
Ensembl
ENSG00000012223
,
ENSP00000405719
,
ENST00000426532
,
ENST00000231751
,
ENSP00000231751
PRO
P02788
Pharos - Targets
P02788
HMDB Protein
HMDBP02010
PDB
1BKA
,
1B0L
,
1LFH
,
1SQY
,
1LFI
,
7N88
,
1DSN
,
2PMS
,
1U62
,
1H43
,
7JRD
,
2BJJ
,
1XV7
,
1H44
,
1LCF
,
1XV4
,
1L5T
,
1N76
,
1VFE
,
1LCT
,
1VFD
,
1LGB
,
1Z6V
,
1H45
,
2HD4
,
1Z6W
,
2GMD
,
1LFG
,
2DP4
,
2GMC
,
1FCK
,
1CB6
,
1HSE
,
1EH3
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27958-PRO_0000037570
0.753
9
UniProt:P62157 CALM
1
Calmodulin [cytosol]
(R-BTA-74015)
0.558
2
UniProt:P27958-PRO_0000037569
0.544
3
UniProt:Q9H8H2 DDX31
0.527
2
UniProt:Q6B0K9 HBM
0.527
2
UniProt:Q8N878 FRMD1
0.527
2
UniProt:Q659A1 ICE2
1
ICE2 [nucleoplasm]
(R-HSA-6807421)
0.527
2
UniProt:Q9HA64 FN3KRP
1
FN3KRP [cytosol]
(R-HSA-6788875)
0.527
2
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