Reactome | NCF2 [cytosol]

NCF2 [cytosol]

Stable Identifier

R-HSA-1222600

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p67phox

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Detoxification of Reactive Oxygen Species (Homo sapiens)
      - NOX2 generates superoxide from oxygen (Homo sapiens)
        
        NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
        
        NCF2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19878 NCF2

Gene Names

NCF2, NOXA2, P67PHOX

Chain

chain:1-526

Reference Genes

BioGPS Gene:4688 NCF2

COSMIC (genes):NCF2 NCF2

CTD Gene:4688 NCF2

dbSNP Gene:4688 NCF2

ENSEMBL:ENSG00000116701 NCF2

HGNC:7661 NCF2

KEGG:hsa:4688 NCF2

Monarch:4688 NCF2

NCBI Gene:4688 NCF2

OMIM:608515 NCF2

UCSC:P19878 NCF2

Reference Transcript

Other Identifiers

11741153_a_at

16697095

209949_PM_at

209949_at

2447415

2447416

2447417

2447418

2447419

2447420

2447421

2447422

2447425

2447426

2447427

2447428

2447429

2447430

2447431

2447432

2447435

2447439

2447441

2447442

2447443

2447445

2447446

2447447

2447448

41038_at

4688

7922773

A_23_P138194

GE57931

GO:0001669

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006801

GO:0006909

GO:0006968

GO:0009055

GO:0016020

GO:0016175

GO:0016176

GO:0016192

GO:0016491

GO:0031267

GO:0031410

GO:0032010

GO:0042554

GO:0043020

GO:0043226

GO:0045087

GO:0045730

GO:0098542

GO:0098772

HMNXSV003013570

ILMN_1796642

M32011_at

PH_hs_0000123

TC01003616.hg

g12804408_3p_at

Participates

as a member of

NCF2,NOXA1 [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

p-T233-NCF2 [phagolysosome]

Inferred To

NCF2 [cytosol] (Bos taurus)

NCF2 [cytosol] (Canis familiaris)

NCF2 [cytosol] (Gallus gallus)

NCF2 [cytosol] (Schizosaccharomyces pombe)

NCF2 [cytosol] (Sus scrofa)

Ncf2 [cytosol] (Mus musculus)

Ncf2 [cytosol] (Rattus norvegicus)

Ghost homologue of NCF2 [cytosol] (Saccharomyces cerevisiae)

ncf2 [cytosol] (Danio rerio)

ncf2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011507883.1, NP_001177723.1, XP_011507882.1, NP_001177718.1, NP_001121123.1, NP_000424.2

OpenTargets

ENSG00000116701

ENSEMBL

ENSP00000407217, ENST00000413720, ENST00000697330, ENSP00000513258, ENSP00000399294, ENST00000367536, ENST00000418089, ENSP00000356505, ENST00000367535, ENSP00000356506

HPA

ENSG00000116701-NCF2

PRO

P19878

Pharos - Targets

P19878

Orphanet

NCF2

PDB

8WEJ, 1WM5, 1K4U, 1HH8, 2DMO, 1E96, 1OEY

HMDB Protein

HMDBP01614

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.926	14
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.805	9
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.676	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.658	3
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.544	3
UniProt:P27870 Vav1	5	p-Y-Vav1 [cytosol] (R-MMU-9029091) phospho-Vav1 [plasma membrane] (R-MMU-389323) phospho-Vav1 [cytosol] (R-MMU-437946) Vav1 [cytosol] (R-MMU-434625) Vav1 [plasma membrane] (R-MMU-1045153)	0.524	4