Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL

Stable Identifier
R-HSA-1225894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
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As inferred from the response of the activin receptor to activin, the type II component of the NODAL receptor phosphorylates the type I component in response to NODAL binding. As inferred from mouse and frog (Xenopus) NODAL can signal via the ACVR1C (ALK7) type I activin receptor (Reissman et al. 2001) though this may be dispensable for development in mouse (Jornvall et al. 2004).

Literature References
PubMed ID Title Journal Year
21356369 Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia

Caniggia, I, Lye, S, Dunk, C, Peng, C, Munir, S, Nadeem, L, Baczyk, D, Fu, G

Am J Pathol 2011
21383881 Nodal and activin receptor-like kinase 7 induce apoptosis in human breast cancer cell lines: Role of caspase 3

Peng, C, Ye, G, Lee, D, Zhong, Y, Modica-Amore, J, Xu, G

Int J Physiol Pathophysiol Pharmacol 2009
11485994 The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Jörnvall, H, Andersson, O, Minchiotti, G, Blokzijl, A, Persico, MG, Reissmann, E, Chang, C, Brivanlou, AH, Ibáñez, CF

Genes Dev 2001
15485907 ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse

Jörnvall, H, Andersson, O, Reissmann, E, Mehrkash, M, Ibáñez, CF

Mol Cell Biol 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane]

Physical Entity
NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
Authored
May, B  (2011-01-23)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-03-03)
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